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The influences of β-glucan associated with BMP-7 on MC3T3-E1 proliferation and osteogenic differentiation
DC Field | Value | Language |
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dc.contributor.author | 박종철 | - |
dc.contributor.author | 백현숙 | - |
dc.contributor.author | 한동욱 | - |
dc.date.accessioned | 2015-08-26T16:38:35Z | - |
dc.date.available | 2015-08-26T16:38:35Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1013-9826 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114839 | - |
dc.description.abstract | b-glucan, an immunomodulator, can selectively enhance the immunobiological activities of neutrophils and macrophages without stimulating proinflammatory cytokine production. Biologic response modifiers, like beta-glucan, will modulate immunity, modify neoplastic disease and increase resistance to microbial challenge. Therefore, beta-glucan polymers can be applied in bone induction and regeneration model and have a possibility of association with bone morphogenetic protein (BMP) because of tissue-regenerative and antimicrobial effects of those polymers. In this report, we studied an E. coli expression system for BMP-7 production and the biological activities of b-glucan associated with BMP-7. The proliferation of MC3T3-E1 osteoblastic cells was enhanced by treatment with Aureobasidium b-glucan, while neither mushroom b-glucan nor barley b-glucan increased the cell proliferation. Mushroom b-glucan alone or associated with BMP-7 increased alkaline phosphatase (ALP) activity of MC3T3-E1 cells, one of the osteoblast phenotype markers, but the other b-glucans did not affect ALP activity of the cells. In mineralization assay, a highly significant increase in nodular staining was observed in cultures treated with both mushroom and Aureobasidium b-glucans in the presence of BMP-7 compared with nontreated controls, while barley b-glucan showed a significant decrease in nodule number compared with cultures treated only with BMP-7. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 241~244 | - |
dc.relation.isPartOf | Key Engineering Materials | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Alkaline Phosphatase | - |
dc.subject.MESH | Bone Mineralization | - |
dc.subject.MESH | Bone Morphogenetic Protein | - |
dc.subject.MESH | MC3T3-E1 Cell | - |
dc.subject.MESH | Osteoblast | - |
dc.subject.MESH | β-Glucan | - |
dc.title | The influences of β-glucan associated with BMP-7 on MC3T3-E1 proliferation and osteogenic differentiation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Medical Engineering (의학공학) | - |
dc.contributor.googleauthor | D.H. Lee | - |
dc.contributor.googleauthor | Dong Wook Han | - |
dc.contributor.googleauthor | Jong Chul Park | - |
dc.contributor.googleauthor | Kazufumi Tsubaki | - |
dc.contributor.googleauthor | M. Aihara | - |
dc.contributor.googleauthor | K. Takatori | - |
dc.contributor.googleauthor | Hyun Sook Baek | - |
dc.contributor.googleauthor | B.J. Park | - |
dc.identifier.doi | 10.4028/www.scientific.net/KEM.288-289.241 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01662 | - |
dc.contributor.localId | A01843 | - |
dc.contributor.localId | A04275 | - |
dc.relation.journalcode | J01939 | - |
dc.identifier.pmid | 10.4028/www.scientific.net/KEM.288-289.241 | - |
dc.identifier.url | http://www.scientific.net/KEM.288-289.241 | - |
dc.subject.keyword | Alkaline Phosphatase | - |
dc.subject.keyword | Bone Mineralization | - |
dc.subject.keyword | Bone Morphogenetic Protein | - |
dc.subject.keyword | MC3T3-E1 Cell | - |
dc.subject.keyword | Osteoblast | - |
dc.subject.keyword | β-Glucan | - |
dc.contributor.alternativeName | Park, Jong Chul | - |
dc.contributor.alternativeName | Baek, Hyun Sook | - |
dc.contributor.alternativeName | Han, Dong Wook | - |
dc.contributor.affiliatedAuthor | Park, Jong Chul | - |
dc.contributor.affiliatedAuthor | Baek, Hyun Sook | - |
dc.contributor.affiliatedAuthor | Han, Dong Wook | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 288~289 | - |
dc.citation.startPage | 241 | - |
dc.citation.endPage | 244 | - |
dc.identifier.bibliographicCitation | Key Engineering Materials, Vol.288~289 : 241-244, 2005 | - |
dc.identifier.rimsid | 38508 | - |
dc.type.rims | ART | - |
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