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Exercise intolerance in patients with atrial fibrillation: Clinical and echocardiographic determinants of exercise capacity

Authors
 Sang Hak Lee  ;  Jae-Hun Jung  ;  Yung Lee  ;  Kwang-Hwak Lee  ;  Chong-Yun Rhim  ;  Kyu-Hyung Ryu  ;  Dong-Jin Oh  ;  Namho Lee  ;  Seung-Hyuk Choi 
Citation
 JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, Vol.18(12) : 1349-1354, 2005 
Journal Title
 JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY 
ISSN
 0894-7317 
Issue Date
2005
MeSH
Atrial Fibrillation/complications ; Atrial Fibrillation/diagnostic imaging* ; Atrial Fibrillation/physiopathology ; Biomarkers/blood ; Exercise Test/methods* ; Exercise Tolerance* ; Female ; Humans ; Male ; Middle Aged ; Natriuretic Peptide, Brain/blood ; Risk Assessment/methods* ; Risk Factors ; Stroke Volume* ; Ultrasonography ; Ventricular Dysfunction, Left/diagnostic imaging* ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/physiopathology
Keywords
16376765
Abstract
Although exercise intolerance is a major symptom of patients with atrial fibrillation (AF), the factors limiting these patients' exercise capacity remains uncertain. This study evaluated the correlation of clinical and echocardiographic parameters with exercise capacity of patients with AF. In all, 73 patients (61 men and 12 women; mean age 61 years) with chronic AF were included in this study. Those patients with primary valvular diseases were excluded. Standard 2-dimensional and Doppler echocardiography was performed, and we averaged 10 consecutive measurements of each variable. Patients then underwent a symptom-limited treadmill exercise testing. We also measured patients' plasma levels of B-type natriuretic peptide before exercise testing. Of all clinical and echocardiographic parameters we assessed, age (r = -0.45, P = .006), ratio of early mitral inflow velocity to mitral annular velocity (r = -0.35, P = .032), and baseline heart rate were independent predictors of exercise capacity on multivariate regression analysis. In conclusion, patient's age, averaged ratio of early mitral inflow velocity to mitral annular velocity, and baseline heart rate provided useful information on exercise intolerance for patients with AF. Ratio of early mitral inflow velocity to mitral annular velocity, a noninvasive tool for estimating left ventricular filling pressure, may especially have important value for predicting functional capacity in this population as it has in individuals with in sinus rhythm.
Full Text
http://www.sciencedirect.com/science/article/pii/S0894731705003330
DOI
10.1016/j.echo.2005.04.007
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Oh, Dong Jin(오동진)
Lee, Nam Ho(이남호)
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Choi, Seung Hyuk(최승혁)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114802
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