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The synaptic microcircuitry associated with primary afferent terminals in the interpolaris and caualis of trigeminal sensory nuclear complex

Authors
 Yong Chul Bae  ;  Hyung Joon Ahn  ;  Yoshio Shigenaga  ;  Masayuki Moritani  ;  Atsushi Yoshida  ;  Kyung Hwan Kim  ;  Hyun Won Lee  ;  Jin Young Bae  ;  Sang Kyoo Paik  ;  Hyun Nam Kim  ;  Kuk Pil Park 
Citation
 BRAIN RESEARCH, Vol.1060(1-2) : 118-125, 2005 
Journal Title
 BRAIN RESEARCH 
ISSN
 0006-8993 
Issue Date
2005
MeSH
Afferent Pathways/cytology ; Afferent Pathways/ultrastructure ; Animals ; Cats ; Microscopy, Electron, Transmission ; Neurons, Afferent/ultrastructure* ; Presynaptic Terminals/ultrastructure* ; Trigeminal Nuclei/cytology ; Trigeminal Nuclei/ultrastructure* ; Vibrissae/innervation
Keywords
Intraaxonal ; Horseradish peroxidase ; Ultrastructure ; Presynaptic ; Postsynaptic
Abstract
Previous ultrastructural studies indicating a higher number of axoaxonic contacts on individual low-threshold mechanoreceptive afferents in the principalis (Vp) than in the oralis (Vo) of cat trigeminal sensory nuclear complex (TSNC) suggest that the synaptic microcircuitry associated with primary afferents manifests unique differences across the sensory nuclei of TSNC. To address this issue, we analyzed synaptic microcircuits associated with fast adapting vibrissa afferent terminals in the interpolaris (Vi) and caudalis (Vc, laminae III/IV) by using intraaxonal injections of horseradish peroxidase (HRP) in cats. Forty-two and 65 HRP-labeled boutons were analyzed in the Vi and Vc, respectively. The labeled boutons contained clear, spherical vesicles. They most frequently formed asymmetric axodendritic synapses and were commonly postsynaptic to unlabeled axon terminals containing pleomorphic vesicles (p-endings) with symmetric junctions. The examination of synaptic contacts over the entire surface of individual boutons indicated that the afferent boutons made contacts with an average of two postsynaptic targets in the Vi and Vc. In contrast, axoaxonic contacts, and labeled boutons participating in synaptic triads, where p-endings contacted both the boutons and their postsynaptic targets, were, on average, higher in the Vi than in the Vc. These results suggest that the output of sensory information conveyed through low-threshold mechanoreceptive afferents is more strongly controlled at the level of the first synapse by presynaptic and postsynaptic mechanisms in the Vi responsible for sensory discriminative functions than in the Vc for sensorimotor reflexive functions.
Full Text
http://www.sciencedirect.com/science/article/pii/S0006899305012576
DOI
10.1016/j.brainres.2005.08.042
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Orofacial Pain and Oral Medicine (구강내과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Hyoung Joon(안형준)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114795
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