The case for strategic international alliances to harness nutritional genomics for public and personal health
Authors
Jim Kaput ; Jose M. Ordovas ; Jean-Daniel Zucker ; Xi Zhao-Wilson ; George L. Wolff ; Jack Winkler ; John Wiencke ; Rick Weiss ; Craig Warden ; Willard J. Visek ; Ricardo Uauy ; Paul Trayhurn ; Bradford Towne ; E. Shyong Tai ; Sue Southon ; Artemis P. Simopoulos ; Andrew N. Shelling ; Gertrud Schuster ; Wim H.M. Saris ; Matthew Roberts ; Kaisa Poutanen ; Francisco Perez-Jimenez ; Norma Pensel ; Taesun Park ; Frans van der Oudera ; Yuri Nikolsky ; Michael Muller ; Peter Morgan ; John A. Milner ; Warren McNabb ; Michael Mayne ; John Mathers ; Su-Ju Lin ; Gilbert A. Leveille ; Jong Ho Lee ; Denis R. Lauren ; Dominique Langin ; David W. Krempin ; Kenneth Kornman ; Bruce R. Korf ; Berthold Koletzko ; Warren A. Kibbe ; Mitchell Kanter ; Claudine Junien ; Hans Joost ; Yangsoo Jang ; Jean-Philippe Jais ; Jae-Kwan Hwang ; Lin He ; John L. Hartman IV ; Jan-Ake Gustafsson ; Peter J. Gillies ; Michael J. Gibney ; Rosalynn Gill-Garrison ; Nancy Fogg-Johnson ; John W. Finley ; Michael Fenech ; Jim Felton ; Susan Fairweather-Tait ; Ruan Elliott ; Sven O. E. Ebbesson ; Troy Duster ; Hannelore Daniel ; Ivana Beatrice Manica da Cruz ; Dolores Corella ; Craig A. Cooney ; Karine Clément ; Stephen Clarke ; Ruth Chadwick ; David Castle ; Rosane Caetano ; Kenneth H. Brown ; Kent J. Bradford ; Peter van Bladeren ; Ruth Birk ; Amelia Bartholomew ; Stephen Barnes ; Michael C. Archer ; Wasyl Malyj ; Ronald Krauss ; Bruce German ; Kevin Dawson ; Bruce N. Ames ; Lindsay Allen ; Raymond L. Rodriguez ; Ben van Ommen ; Lynnette Ferguson
Citation
BRITISH JOURNAL OF NUTRITION, Vol.94(5) : 623-632, 2005
Animals ; Disease Models, Animal ; Eating ; Environment ; Genetic Variation/genetics ; Genome, Human ; Genomics* ; Humans ; International Cooperation ; Nutritional Physiological Phenomena/physiology* ; Phenotype ; Research
Keywords
16277761
Abstract
Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.