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Involvement of CLOCK : BMALI heterodimer in serum-responsive mPerl induction
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정호성 | - |
dc.date.accessioned | 2015-07-15T17:19:31Z | - |
dc.date.available | 2015-07-15T17:19:31Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0959-4965 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114679 | - |
dc.description.abstract | A rapid induction of mouse period1 (mPer1) gene expression is supposed to be critical in the clock gene regulation, especially in the phase resetting of the clock, but its molecular mechanism is poorly understood. Based on the previous finding that the process does not involve de novo synthesis of proteins, we postulated the involvement of CLOCK:BMAL1 heterodimer, a positive regulator of circadian oscillator, in the rapid induction of mPer1 transcription. To test this hypothesis, we utilized CLOCK[DELTA]19, a dominant-negative mutant, to suppress the function of CLOCK:BMAL1 in vitro. Serum-evoked rapid increases of mPer1 mRNA expression and promoter activity were significantly blunted when CLOCK:BMAL1 function was interfered with. Furthermore, DNA binding activity of CLOCK:BMAL1 heterodimer to five E-boxes of mPer1 promoter markedly increased shortly after serum shock. Taken together, these results suggest that CLOCK:BMAL1 heterodimer is not only a core component of negative feedback loop driving circadian oscillator, but also involved in the rapid induction of mPer1 during phase resetting of the clock. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 15~19 | - |
dc.relation.isPartOf | NEUROREPORT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 3T3 Cells/drug effects | - |
dc.subject.MESH | ARNTL Transcription Factors | - |
dc.subject.MESH | Alleles | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Basic Helix-Loop-Helix Transcription Factors | - |
dc.subject.MESH | CLOCK Proteins | - |
dc.subject.MESH | Cattle | - |
dc.subject.MESH | Cell Cycle Proteins | - |
dc.subject.MESH | Circadian Rhythm/physiology* | - |
dc.subject.MESH | Culture Media, Serum-Free/pharmacology | - |
dc.subject.MESH | DNA/genetics | - |
dc.subject.MESH | DNA/metabolism | - |
dc.subject.MESH | Dimerization | - |
dc.subject.MESH | Feedback, Physiological | - |
dc.subject.MESH | Fetal Blood/physiology | - |
dc.subject.MESH | Gene Expression Regulation/physiology* | - |
dc.subject.MESH | Genes, Dominant | - |
dc.subject.MESH | Genes, Reporter | - |
dc.subject.MESH | Genes, fos | - |
dc.subject.MESH | Luciferases/biosynthesis | - |
dc.subject.MESH | Luciferases/genetics | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Nuclear Proteins/biosynthesis* | - |
dc.subject.MESH | Nuclear Proteins/genetics | - |
dc.subject.MESH | Period Circadian Proteins | - |
dc.subject.MESH | Promoter Regions, Genetic | - |
dc.subject.MESH | Proto-Oncogene Proteins c-fos/biosynthesis | - |
dc.subject.MESH | RNA, Messenger/biosynthesis | - |
dc.subject.MESH | Recombinant Fusion Proteins/physiology | - |
dc.subject.MESH | Trans-Activators/chemistry | - |
dc.subject.MESH | Trans-Activators/genetics | - |
dc.subject.MESH | Trans-Activators/physiology* | - |
dc.subject.MESH | Transcription Factors/chemistry | - |
dc.subject.MESH | Transcription Factors/physiology* | - |
dc.subject.MESH | Transfection | - |
dc.title | Involvement of CLOCK : BMALI heterodimer in serum-responsive mPerl induction | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anatomy (해부학) | - |
dc.contributor.googleauthor | Hosung Jung | - |
dc.contributor.googleauthor | Youngshik Choe | - |
dc.contributor.googleauthor | Kyungjin Kim | - |
dc.contributor.googleauthor | Inkoo Khang | - |
dc.contributor.googleauthor | Gi Hoon Son | - |
dc.contributor.googleauthor | Noheon Park | - |
dc.contributor.googleauthor | Hyunjung Kim | - |
dc.identifier.doi | 10.1097/01.wnr.0000050715.17082.d2 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03786 | - |
dc.relation.journalcode | J02361 | - |
dc.identifier.eissn | 1473-558X | - |
dc.identifier.pmid | 12544823 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-200301200-00003&LSLINK=80&D=ovft | - |
dc.subject.keyword | Bmal1 | - |
dc.subject.keyword | Clock | - |
dc.subject.keyword | Mouse period 1 (mPer1) | - |
dc.subject.keyword | NIH-3T3 mouse ¢broblas tcells | - |
dc.subject.keyword | Serum shock | - |
dc.subject.keyword | Transcrip tional regula tion | - |
dc.contributor.alternativeName | Jung, Ho Sung | - |
dc.contributor.affiliatedAuthor | Jung, Ho Sung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 14 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 15 | - |
dc.citation.endPage | 19 | - |
dc.identifier.bibliographicCitation | NEUROREPORT, Vol.14(1) : 15-19, 2003 | - |
dc.identifier.rimsid | 46055 | - |
dc.type.rims | ART | - |
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