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Melanocins A, B and C, new melanin synthesis inhibitors produced by Eupenicillium shearii - I. Taxonomy, fermentation, isolation and biological properties
DC Field | Value | Language |
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dc.contributor.author | 이창환 | - |
dc.date.accessioned | 2015-07-15T17:18:32Z | - |
dc.date.available | 2015-07-15T17:18:32Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0021-8820 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114648 | - |
dc.description.abstract | New melanin synthesis inhibitors, melanocins A, B and C, were isolated from the fermentation broth and mycelium extract of Eupenicillium shearii F80695. Melanocin A, an isocyanide compound, inhibited mushroom tyrosinase and melanin biosynthesis of B16 melanoma cells with IC50 value of 9.0 nM and MIC value of 0.9 microM, respectively. Melanocin A also inhibited growth of Streptomyces bikiniensis. While, the structurally very related but non-isocyanide compounds melanocins B and C did not show inhibitory activity in these assays. Melanocins A, B and C showed potent antioxidant activity with scavenging activity of DPPH radical and superoxide anion radical. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | JOURNAL OF ANTIBIOTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Agaricales/enzymology | - |
dc.subject.MESH | Anti-Bacterial Agents/isolation & purification | - |
dc.subject.MESH | Anti-Bacterial Agents/pharmacology | - |
dc.subject.MESH | Ascomycota/classification | - |
dc.subject.MESH | Ascomycota/metabolism* | - |
dc.subject.MESH | Butanones/isolation & purification | - |
dc.subject.MESH | Butanones/pharmacology | - |
dc.subject.MESH | Cyanides/isolation & purification | - |
dc.subject.MESH | Cyanides/pharmacology | - |
dc.subject.MESH | Enzyme Inhibitors/isolation & purification | - |
dc.subject.MESH | Enzyme Inhibitors/pharmacology | - |
dc.subject.MESH | Formamides/isolation & purification | - |
dc.subject.MESH | Formamides/pharmacology | - |
dc.subject.MESH | Free Radical Scavengers/isolation & purification | - |
dc.subject.MESH | Free Radical Scavengers/pharmacology | - |
dc.subject.MESH | Melanins/antagonists & inhibitors* | - |
dc.subject.MESH | Melanins/biosynthesis | - |
dc.subject.MESH | Monophenol Monooxygenase/antagonists & inhibitors | - |
dc.subject.MESH | Streptomyces/drug effects | - |
dc.subject.MESH | Streptomyces/growth & development | - |
dc.title | Melanocins A, B and C, new melanin synthesis inhibitors produced by Eupenicillium shearii - I. Taxonomy, fermentation, isolation and biological properties | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Medical Research Center (임상의학연구센터) | - |
dc.contributor.googleauthor | JONG-PYUNG KIM | - |
dc.contributor.googleauthor | BYOUNG-KWON KIM | - |
dc.contributor.googleauthor | ICK-DONG YOO | - |
dc.contributor.googleauthor | YU-RYANG PYUN | - |
dc.contributor.googleauthor | SANGKU LEE | - |
dc.contributor.googleauthor | WON-GON KIM | - |
dc.contributor.googleauthor | IN-KYOUNG LEE | - |
dc.contributor.googleauthor | CHOONG HWAN LEE | - |
dc.contributor.googleauthor | IN-JA RYOO | - |
dc.contributor.googleauthor | BONG-SIK YUN | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03249 | - |
dc.relation.journalcode | J01236 | - |
dc.identifier.pmid | 15015725' | - |
dc.subject.keyword | 15015725' | - |
dc.contributor.alternativeName | Lee, Choong Hwan | - |
dc.contributor.affiliatedAuthor | Lee, Choong Hwan | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 56 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 993 | - |
dc.citation.endPage | 999 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ANTIBIOTICS, Vol.56(12) : 993-999, 2003 | - |
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