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Signalling specificity in GPCR-dependent Ca2+ signalling
DC Field | Value | Language |
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dc.contributor.author | 신동민 | - |
dc.date.accessioned | 2015-07-15T17:16:30Z | - |
dc.date.available | 2015-07-15T17:16:30Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0898-6568 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114581 | - |
dc.description.abstract | Cells use signalling networks to translate with high fidelity extracellular signals into specific cellular functions. Signalling networks are often composed of multiple signalling pathways that act in concert to regulate a particular cellular function. In the centre of the networks are the receptors that receive and transduce the signals. A versatile family of receptors that detect a remarkable variety of signals are the G protein-coupled receptors (GPCRs). Virtually all cells express several GPCRs that use the same biochemical machinery to transduce their signals. Considering the specificity and fidelity of signal transduction, a central question in cell signalling is how signalling specificity is achieved, in particular among GPCRs that use the same biochemical machinery. Ca2+ signalling is particularly suitable to address such questions, since [Ca2+]i can be recorded with excellent spatial and temporal resolutions in living cells and tissues and now in living animals. Ca2+ is a unique second messenger in that both biochemical and biophysical components form the Ca2+ signalling complex to regulate its concentration. Both components act in concert to generate repetitive [Ca2+]i oscillations that can be either localized or in the form of global, propagating Ca2+ waves. Most of the key proteins that form Ca2+ signalling complexes are known and their activities are reasonably well understood on the biochemical and biophysical levels. We review here the information gained from studying Ca2+ signalling by GPCRs to gain further understanding of the mechanisms used to generate cellular signalling specificity. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 243~253 | - |
dc.relation.isPartOf | CELLULAR SIGNALLING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Calcium Signaling/physiology* | - |
dc.subject.MESH | GTP-Binding Proteins/physiology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Receptors, Cell Surface/physiology* | - |
dc.title | Signalling specificity in GPCR-dependent Ca2+ signalling | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Kirill Kiselyov | - |
dc.contributor.googleauthor | Dong Min Shin | - |
dc.contributor.googleauthor | Shmuel Muallem | - |
dc.identifier.doi | 10.1016/S0898-6568(02)00074-8 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02091 | - |
dc.relation.journalcode | J00502 | - |
dc.identifier.eissn | 1873-3913 | - |
dc.identifier.pmid | 12531423 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0898656802000748 | - |
dc.subject.keyword | 12531423 | - |
dc.contributor.alternativeName | Shin, Dong Min | - |
dc.contributor.affiliatedAuthor | Shin, Dong Min | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 15 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 243 | - |
dc.citation.endPage | 253 | - |
dc.identifier.bibliographicCitation | CELLULAR SIGNALLING, Vol.15(3) : 243-253, 2003 | - |
dc.identifier.rimsid | 40043 | - |
dc.type.rims | ART | - |
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