Neuropathic Pain의 조절에 있어서 Lidocaine과 Opioid 및NMDA 수용체에 작용하는 약물의 상호작용

Abstract

Background: Opioids have been shown to be ineffective in relieving neuropathic pain. The present study was conducted to evaluate whether there is any interaction between lidocaine and opioid or NMDA receptor agents in the modulation of neuropathic pain. Methods: Under pentobarbital anesthesia, male Sprague-Dawley rats were subjected to nerve injury. After behavioral tests for neuropathic pain, electrophysiological study was performed to apply lidocaine, naloxone (opioid antagonist), MK-801 (NMDA antagonist) microiontophoretically. Results: Microiontophoretically applied lidocaine and MK-801 reduced the responses of spinal neuros to mechanical or thermal stimulation. Naloxone alone did not inhibit neural responses to external stimuli but reversed the inhibitory effects of lidocaine, indicating an interaction between lidocaine and naloxone. We could not observe any interaction between lidocaine and MK-801. Conclusions: The results suggest that there is an interaction between lidocaine and opioid receptors. Combinational treatment of two or more chemicals may be useful to treat neuropathic pain.