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척수손상으로 유도된 백서의 통각과민 반응에서 항신경성장인자의 복강 내 주입에 의한 통증 완화 효과

Other Titles
 Attenuation of Spinal Cord Injury-induced Hyperalgesia by Administration of Antibody to Nerve Growth Factor in the Rat 
 곽영섭  ;  배정윤  ;  임중우  ;  백광세  ;  남택상  ;  윤덕미  ;  장준호 
 Korean Journal of Pain (대한통증학회지), Vol.16(1) : 7-13, 2003 
Journal Title
 Korean Journal of Pain (대한통증학회지) 
Issue Date
anti-nerve growth factor ; central pain ; mechanical hyperalgesia ; spinal cord injury ; wide dynamic range neurons
anti-nerve growth factor ; central pain ; mechanical hyperalgesia ; spinal cord injury ; wide dynamic range neurons
Background: Spinal cord injury (SCI) often leads to central pain syndrome, including hyperalgesia to mechanical stimulation. Since there is evidence that nerve growth factor (NGF) contributes to pain-related behaviors, we wanted to determine if anti-NGF might inhibit the abnormal somatosensory behaviors that develop following SCI in rats. Methods: SCI was performed in male Sprague Dawley rats by T13 spinal hemisection. After the spinal hemisection, the animals were treated daily with anti-NGF or saline intraperitoneally for 10 days or left untreated. Extracellular recordings of neuronal activity were made from the dorsal horn neurons in the lumbar spinal cord (L4-L5), using a recording glass microelectrode. The single unit responses of the neurons to mechanical stimuli, applied to the receptive fields, were analyzed. The wide dynamic range (WDR) neurons, which were characterized by their graded responses to increased intensities of mechanical stimuli, were subjected to the investigation. Results: In both the hemisection only and hemisection with saline treatment groups, mechanical hyperalgesia developed in both hind limbs, as evidenced by a decrease in the paw withdrawal thresholds. The mechanical responsiveness of the WDR neurons on both sides of the spinal cord also increased. The anti-NGF treated group demonstrated significant suppression of both the mechanical hyperalgesia and increased WDR neuronal responsiveness. Conclusions: These results indicate that anti-NGF prevents the development of abnormal somatosensory behavior, suggestive of a potential pre-emptive analgesic treatment for central pain.
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1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Nam, Taick Sang(남택상)
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