Cited 183 times in
Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-κB activation and tumor promotion
DC Field | Value | Language |
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dc.contributor.author | 박광균 | - |
dc.date.accessioned | 2015-07-15T17:10:56Z | - |
dc.date.available | 2015-07-15T17:10:56Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0027-5107 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114393 | - |
dc.description.abstract | Our previous studies demonstrated the anti-oxidant and anti-tumor promotional properties of the methanol extract of heat-processed Panax ginseng C.A. Meyer [Cancer Lett. 150 (2000) 41]. In the present work, we have evaluated anti-inflammatory as well as anti-tumor promoting effects of Rg3, a major ginsenoside derived from heat-processed ginseng. Pretreatment of dorsal skins of female ICR mice with Rg3 significantly inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase activity and 7,12-dimethylbenz[a]anthracene-initiated papilloma formation. In another experiment, Rg3 pretreatment abrogated the expression of cyclooxygenase-2 in TPA-stimulated mouse skin. Rg3 also inhibited the TPA-induced activation of the eukaryotic transcription factor, NF-κB in both mouse skin and cultured human pro-myelocytic leukemia (HL-60) cells. Moreover, Rg3 exerted potent inhibitory effects on the activation of another transcription factor, activator protein-1 (AP-1) that is responsible for c-jun and c-fos oncogenic transactivation. Based on these findings, it is likely that the anti-tumor promoting activity of Rg3 is mediated possibly through down-regulation of NF-κB and AP-1 transcription factors. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 75~85 | - |
dc.relation.isPartOf | MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anti-tumor promotion | - |
dc.subject.MESH | AP-1 | - |
dc.subject.MESH | Cyclooxygenase-2 | - |
dc.subject.MESH | Ginseng | - |
dc.subject.MESH | Ginsenoside Rg3 | - |
dc.subject.MESH | HL-60 cells | - |
dc.subject.MESH | Mouse skin carcinogenesis | - |
dc.subject.MESH | NF-κB | - |
dc.title | Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-κB activation and tumor promotion | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Young-Sam Keum | - |
dc.contributor.googleauthor | Seong Su Han | - |
dc.contributor.googleauthor | Young-Joon Surh | - |
dc.contributor.googleauthor | Seung Ki Lee | - |
dc.contributor.googleauthor | Jeong-Hill Park | - |
dc.contributor.googleauthor | Kwang-Kyun Park | - |
dc.contributor.googleauthor | Kyung-Soo Chun | - |
dc.identifier.doi | 10.1016/S0027-5107(02)00323-8 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01429 | - |
dc.relation.journalcode | J02279 | - |
dc.identifier.eissn | 1873-135X | - |
dc.identifier.pmid | 10.1016/S0027-5107(02)00323-8 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0027510702003238 | - |
dc.subject.keyword | Anti-tumor promotion | - |
dc.subject.keyword | AP-1 | - |
dc.subject.keyword | Cyclooxygenase-2 | - |
dc.subject.keyword | Ginseng | - |
dc.subject.keyword | Ginsenoside Rg3 | - |
dc.subject.keyword | HL-60 cells | - |
dc.subject.keyword | Mouse skin carcinogenesis | - |
dc.subject.keyword | NF-κB | - |
dc.contributor.alternativeName | Park, Kwang Kyun | - |
dc.contributor.affiliatedAuthor | Park, Kwang Kyun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 523~524 | - |
dc.citation.startPage | 75 | - |
dc.citation.endPage | 85 | - |
dc.identifier.bibliographicCitation | MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, Vol.523~524 : 75-85, 2003 | - |
dc.identifier.rimsid | 47274 | - |
dc.type.rims | ART | - |
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