2 273

Cited 156 times in

Neural correlates of clinical symptoms and cognitive dysfunctions in obsessive–compulsive disorder

 Jun Soo Kwon  ;  Jae-Jin Kim  ;  Myung Chul Lee  ;  Maeng Je Cho  ;  In Kyoon Lyoo  ;  Myung-Sun Kim  ;  Dong Soo Lee  ;  Jae Sung Lee  ;  Dong Woo Lee 
 PSYCHIATRY RESEARCH, Vol.122(1) : 37-47, 2003 
Journal Title
Issue Date
Adult ; Brain/metabolism* ; Brain/physiopathology* ; Cognition Disorders/diagnosis ; Cognition Disorders/etiology* ; Cognition Disorders/physiopathology* ; Corpus Striatum/metabolism ; Corpus Striatum/physiopathology ; Female ; Fluorodeoxyglucose F18 ; Frontal Lobe/metabolism ; Frontal Lobe/physiopathology ; Humans ; Male ; Neural Pathways/metabolism ; Neural Pathways/physiopathology ; Neuropsychological Tests ; Obsessive-Compulsive Disorder/complications* ; Radiopharmaceuticals ; Severity of Illness Index ; Tomography, Emission-Computed*
Obsessive–compulsive disorder ; FDG-PET ; Voxel-based analysis ; Cognitive dysfunction ; Neural correlates ; Frontal-subcortical circuits
Although results from neuropsychological and neuroimaging studies have postulated the involvement of the frontal lobe and the subcortical brain regions in the pathophysiology of obsessive–compulsive disorder (OCD), neuroimaging studies have provided little evidence that cognitive abnormalities in patients with OCD are related to dysfunctions in these areas. This study was designed to determine whether the clinical features and cognitive deficits of OCD might be taken to reflect frontal-subcortical dysfunction. Fourteen patients with OCD and 14 case-matched normal subjects completed clinical and cognitive evaluation, including four sets of neuropsychological tests that assessed the executive functions and visual memory. Cerebral glucose metabolic rates were measured by using positron emission tomography (PET) with 18F-fluorodeoxyglucose. Behavioral and PET data were analyzed using statistical parametric mapping for group differences and behavioral–metabolic correlates. The right orbitofrontal cortex showed increased metabolic activity and the left parieto-occipital junction showed decreased metabolic activity in patients. Metabolism in the right hippocampus, the left putamen and the right parietal region was associated with the severity of obsessive–compulsive symptoms. Correlations between metabolic rates and neuropsychological test scores in the prefrontal cortex and the putamen occurred only in the patient group. These results suggest that patients with OCD have distinct features of brain metabolic activities for performing cognitive tasks as well as presenting obsessive–compulsive symptoms. In particular, the frontal–subcortical circuits might mediate not only symptomatic expression but also cognitive expression in patients with OCD.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.