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Transient panhypogammaglobulinaemia and B-lymphocyte deficiency in a patient with neuropsychiatric systemic lupus erythematosus after immunosuppressive therapy

Authors
 J. Song  ;  Y.-B. Park  ;  S.-K. Lee  ;  C.-H. Suh 
Citation
 CLINICAL RHEUMATOLOGY, Vol.22(1) : 62-66, 2003 
Journal Title
 CLINICAL RHEUMATOLOGY 
ISSN
 0770-3198 
Issue Date
2003
MeSH
Adult ; Agammaglobulinemia/chemically induced* ; Agammaglobulinemia/etiology ; B-Lymphocytes* ; Female ; Humans ; Immunosuppressive Agents/adverse effects* ; Lupus Vasculitis, Central Nervous System/complications ; Lupus Vasculitis, Central Nervous System/diagnosis ; Lupus Vasculitis, Central Nervous System/drug therapy* ; Lymphopenia/chemically induced* ; Magnetic Resonance Imaging ; Prednisolone/adverse effects*
Keywords
B lymphocyte ; Hypogammaglobulinaemia ; Immunosuppressive therapy ; systemic lupus erythematosus
Abstract
Panhypogammaglobulinaemia is a rare complication of systemic lupus erythematosus (SLE), but its cause and mechanism are unclear. We observed transient panhypogammaglobulinaemia in a patient with neuropsychiatric SLE after treatment with prednisolone and cyclophosphamide. After the patient developed recurrent infections, laboratory findings disclosed panhypogammaglobulinaemia with B-lymphocyte deficiency. The serum immunoglobulin level returned to the normal range after the prednisolone was tapered off. Because lupus patients are susceptible to infections associated with disease exacerbation or immunosuppressive treatment, recurrent infections might be expected during the disease course without need for further evaluation of the immunodeficiency. However, this reversible, probably drug-induced case of hypogammaglobulinaemia highlights the need for immunoglobulin measurements when immunodeficiency is suspected in lupus patients.
Full Text
http://link.springer.com/article/10.1007%2Fs10067-002-0655-4
DOI
10.1007/s10067-002-0655-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Beom(박용범)
Lee, Soo Kon(이수곤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114347
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