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건강한 한국인 여성에서의 골밀도와 혈청 렙틴의 연관성

Other Titles
 Association between Serum Leptin Concentration and Bone Mineral Density in Healthy Korean Women 
Authors
 이유미  ;  김대중  ;  김세화  ;  안철우  ;  차봉수  ;  김경래  ;  이현철  ;  임승길 
Citation
 Journal of Korea Society of Endocrinology (대한내분비학회지), Vol.18(2) : 177-183, 2003 
Journal Title
 Journal of Korea Society of Endocrinology (대한내분비학회지) 
ISSN
 1015-6380 
Issue Date
2003
MeSH
Serum leptin concentration ; BMD ; Pre-/postmenopause
Keywords
Serum leptin concentration ; BMD ; Pre-/postmenopause
Abstract
Background: Leptin is known to affect bone metabolism both centrally and peripherally. This study was performed to investigate the relationship between leptin and bone mineral density(BMD) in healthy premenopausal and postmenopausal Korean women. Methods: 140 women were recruited for a routine health check-up. Anthro-pometric and biochemical data were checked as usual. BMDs were measured by dual x-ray absorptiometry of the spine and femur in 67 premenopausal women and 73 postmenopausal women, in addition to their serum leptin levels. Results: Serum leptin level showed no correlation with BMD in premenopausal women, but there was a positive correlation betwen serum leptin and spinal BMD in postmenopausal women(r=0.468, p<0.001). After the correcting for age, body mass index, and duration of menopause, the serum leptin level and BMD still showed a positive correlation(r=0.217, p=0.088) although weak. The women in the lowest quartile of serum leptin level showed significantly lower lumbar and femoral neck BMD. Conclusion: Leptin level seems to have a weak relationship with BMD showing different features in premenopausal and postmenopausal women.
Full Text
http://kiss.kstudy.com/journal/thesis_name.asp?tname=kiss2002&key=2106580
DOI
OAK-2003-01178
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114338
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