3 199

Cited 67 times in

About face: signals and genes controlling jaw patterning and identity in vertebrates.

Authors
 Joy M. Richman  ;  Sang-Hwy Lee 
Citation
 BIOESSAYS, Vol.25(6) : 554-568, 2003 
Journal Title
 BIOESSAYS 
ISSN
 0265-9247 
Issue Date
2003
MeSH
Animals ; Body Patterning ; Brain/metabolism ; Cell Differentiation ; Chick Embryo ; Endoderm/metabolism ; Jaw/embryology* ; Jaw/physiology* ; Models, Biological ; Neural Crest/metabolism ; Phenotype ; Signal Transduction*
Keywords
12766945
Abstract
The embryonic vertebrate face is composed of similarly sized buds of neural crest-derived mesenchyme encased in epithelium. These buds or facial prominences grow and fuse together to give the postnatal morphology characteristic of each species. Here we review the role of neural crest cells and foregut endoderm in differentiating facial features. We relate the developing facial prominences to the skeletal structure of the face and review the signals and genes that have been shown to play an important role in facial morphogenesis. We also examine two experiments one at the genetic level and one at the signal level in which transformation of facial prominences and subsequent change of jaw identity was induced. We propose that signals such as retinoids and BMPs and downstream transcription factors such as Distal-less related genes specify jaw identity.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/bies.10288/abstract
DOI
10.1002/bies.10288
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sang Hwy(이상휘) ORCID logo https://orcid.org/0000-0002-9438-2489
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114308
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse