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전국 13개 기관에서 분리된 염색체성 AmpC β-lactamase 생성 Enterobacter Cloacae, citrobacter freundii 및 Serratia marcescens의 항균제감수성 양상

Other Titles
 Antimicrobial Susceptibility of Inducible AmpC β-lactamase-producing Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens 
 박연준  ;  이승옥  ;  강창석  ;  김병기  ;  이경원  ;  용동은 
 Korean Journal of Laboratory Medicine (대한진단검사의학회지), Vol.23(4) : 251-257, 2003 
Journal Title
 Korean Journal of Laboratory Medicine  (대한진단검사의학회지) 
Issue Date
Background :Antimicrobial resista1ce to third-generation cephalosporins in gram-negative bacteria, especially Enterobaeter, Citrobaeter, and Serratia spp., is increasing. The resistance mechanism of these organisms are hyperproduction of AmpC β-lactamase and plasmid-mediated extended-spectrum β-lactamase (ESBL). This study was to determine the ocgurrence of AmpC hyperproduction and ESBLs in E. cloacae, C. freundii, and S. marcescens over a3-month period in 2002. Methods :We tested total of 619 consecutive, nonduplicate isolates (229 E. cloacae, 183 C. freundii, 207 S. marcescens) from 12 university hospitals and a commercial laboratory in Korea. Antimicrobial susceptibilities were tested using the disk diffusion method. AmpC hyperproduction was defined as nonsusceptible to cefotaxime or ceftazidime for E. cloacae and C. freundii and as nonsusceptible to cefotaxime for S. marcescens. ESBL production was determined by the double disk synergy test. Results :Among the E. cloacae, C. freundii and S. marcescens derepressed strains were 20.5%, 30.1 %, and 31.4% and ESBL producers were 23.6%, 10.9%, and 15.5%, respectively. The AmpC derepressed strains and ESBL producers revealed lower susceptibility rates for ciprofloxacin, piperacillin, piperacillin-tazobactam and aminoglycosides Conclusions :These data reveal that the occurrence of AmpC derepressants and ESBL producers among E. cloacae, C. freundii and S. marceseens is relatively high. Continued nationwide surveillance is necessary to provide information on the spread of these important mechanisms of resistance to β-lactams.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
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