1 264

Cited 25 times in

Prediction of buckwheat allergy using specific IgE concentrations in children

Authors
 M. H. Sohn  ;  S. Y. Lee  ;  K.-E. Kim 
Citation
 ALLERGY, Vol.58(12) : 1308-1310, 2003 
Journal Title
 ALLERGY 
ISSN
 0105-4538 
Issue Date
2003
MeSH
Adolescent ; Child ; Child, Preschool ; Fagopyrum/adverse effects* ; Fagopyrum/immunology ; Female ; Food Hypersensitivity/immunology* ; Humans ; Immunoglobulin E/immunology* ; Korea ; Male ; Predictive Value of Tests ; Skin Tests/methods
Keywords
allergy ; buckwheat ; food allergy ; open food challenge test ; specific IgE
Abstract
INTRODUCTION: Buckwheat (BW) is considered to be one of the most important food allergens, and positive skin tests are found in about 5% of Koreans. We investigated the positive and negative predictive values of BW-specific IgE in subjects with a BW allergy in order to reduce the need for buckwheat challenge, which can be more riskier than other causes of food allergies. METHODS: Twenty-eight BW allergic subjects with symptoms after BW Open food challenge and 16 asymptomatic control subjects with positive skin test to BW were recruited. Serum samples from all patients were analyzed for BW-specific IgE antibodies using the Pharmacia CAP System. RESULTS: According to the receiver operator characteristic (ROC) analysis, the optimal cutoff level of BW-specific IgE, as the definitions of serum BW-specific IgE positive, was 1.26 kUA/l. With this selected cutoff level, the sensitivity, specificity, positive and negative predictive values were 93.10, 93.33, 79.75 and 97.96%, respectively. CONCLUSION: The use of the optimal cutoff level, 1.26 kUA/l, that simultaneously maximizes sensitivity and specificity, would be helpful for avoiding unnecessary risky challenge in children with a strong clinical history and skin test responses. PMID: 14616108 [PubMed - indexed for MEDLINE]
Full Text
http://onlinelibrary.wiley.com/doi/10.1046/j.1398-9995.2003.00339.x/abstract
DOI
10.1046/j.1398-9995.2003.00339.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyu Earn(김규언)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114223
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links