Cited 32 times in
Tumor Necrosis Factor-α Levels and Promoter Polymorphism in Patients with Kawasaki Disease in Korea
DC Field | Value | Language |
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dc.contributor.author | 김동수 | - |
dc.contributor.author | 신전수 | - |
dc.date.accessioned | 2015-07-15T17:05:46Z | - |
dc.date.available | 2015-07-15T17:05:46Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114217 | - |
dc.description.abstract | Tumor necrosis factor (TNF)-α plays a major role in the pathogenesis of Kawasaki disease (KD), a systemic vasculitis primarily affecting young children. We performed this study to examine the serum levels of TNF-α and to investigate a possible relation to promoter polymorphism at positions -238 and -308 in KD patients in Korea. We obtained 48 paired serum samples from 24 patients in the acute and subacute stages of KD, and control sera from 12 age-matched children who were having routine blood samples taken before elective surgical procedures. Our studies showed a significant increase in serum levels of TNF-α measured in the acute stage of KD (24.1±9.4 pg/mL) compared to those in the subacute stage (11.8±5.8 pg/mL; p < 0.01) and normal controls (10.4±4.9 pg/mL; p < 0.01). Previous studies report that the presence of the A allele at positions -308 and -238 may be associated with higher TNF-α levels. However, our results showed that the frequency of the A allele at position -308 in the KD patients was the same as the controls (2 out of 24, 8.3% vs. 8.3%, odds ratio (OR) = 1.00), while the frequency of the A allele at position -238 in the KD patients was lower than the controls (0/24, 0% vs. 8.3%, OR=0.00) ; this difference though was not statistically significant. We concluded that although TNF-α levels were significantly elevated in the acute stage of KD, there was no significant difference in the frequency of the A allele at positions -238 and -308 between the KD and control groups in Korean patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1021~1026 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Mucocutaneous Lymph Node Syndrome/blood* | - |
dc.subject.MESH | Mucocutaneous Lymph Node Syndrome/genetics* | - |
dc.subject.MESH | Polymorphism, Genetic* | - |
dc.subject.MESH | Promoter Regions, Genetic/genetics* | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/genetics* | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/metabolism* | - |
dc.title | Tumor Necrosis Factor-α Levels and Promoter Polymorphism in Patients with Kawasaki Disease in Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Sun Young Ahn | - |
dc.contributor.googleauthor | Gwang Cheon Jang | - |
dc.contributor.googleauthor | Dong Soo Kim | - |
dc.contributor.googleauthor | Kyung Mi Shin | - |
dc.contributor.googleauthor | Jeon Soo Shin | - |
dc.identifier.doi | 10.3349/ymj.2003.44.6.1021 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02144 | - |
dc.contributor.localId | A00405 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 14703611 | - |
dc.subject.keyword | Kawasaki disease | - |
dc.subject.keyword | TNF-α | - |
dc.subject.keyword | polymorphism | - |
dc.contributor.alternativeName | Kim, Dong Soo | - |
dc.contributor.alternativeName | Shin, Jeon Soo | - |
dc.contributor.affiliatedAuthor | Shin, Jeon Soo | - |
dc.contributor.affiliatedAuthor | Kim, Dong Soo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 44 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1021 | - |
dc.citation.endPage | 1026 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.44(6) : 1021-1026, 2003 | - |
dc.identifier.rimsid | 41491 | - |
dc.type.rims | ART | - |
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