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백서에서 포르말린 피하주사에 의한 척수후각신경세포의 발화 생성에 Glutamate 수용체와 GABA 수용체의 역할

Other Titles
 A Role of Glutamate and GABA Receptors in the Generation of Formalin-induced Impulse Firing of Spinal Dorsal Horn Neurons in the Rat 
 배정윤  ;  장준호  ;  백광세  ;  남택상  ;  임중우  ;  윤덕미  ;  전영훈 
 Korean Journal of Pain (대한통증학회지), Vol.16(2) : 118-132, 2003 
Journal Title
 Korean Journal of Pain (대한통증학회지) 
Issue Date
Formalin ; GABA ; Glutamate ; Inflammation ; Pain
Formalin ; GABA ; Glutamate ; Inflammation ; Pain
BACKGROUND: A peripheral subcutaneous injection of formalin produces biphasic impulse firing of the spinal nociceptive neurons. The roles of excitatory glutamatergic and inhibitory GABAergic receptors were investigated in the formalin-induced impulse generation of rat spinal neurons. METHODS: The neuronal activity was recorded, extracellularly, from the spinal nociceptive neurons of rats spinalized at L1. Formalin (2.5%, 50mul) was injected into the plantar spot near the receptive field of the recorded neuron. Agonists and antagonists, for glutamatergic and GABAergic receptors, were applied topically onto the surface of the spinal cord near the recording electrode. RESULTS: The plantar injection of formalin evoked typical biphasic firing of the spinal neurons. When applied before the formalin injection, AMPA receptor antagonists blocked the first firing, while the receptor antagonist, NMDA and mGlu, blocked the second firing. When applied before the formalin injection, or during the interphase, receptor antagonists, GABA-A and GABA-B, facilitated the second firing to occur. When applied during the second firing, the receptor antagonists, NMDA, AMPA and mGlu, all blocked the second firing, while the receptor antagonists, GABA-A and GABA-B, had no effect. CONCLUSIONS: The results indicated that: 1) the formalin-produced first firing is mediated by AMPA receptor activation, 2) the first firing is followed by GABAergic inhibition, which contributes to the formation of the interphase, via activation of GABA-A and GABA-B receptors, and 3) the induction of the second firing is mediated by the diminution of GABAergic inhibition, as well as the activation of the NMDA and mGlu receptors, while being mediated in its maintenance by the activation of NMDA, AMPA and mGlu receptors.
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1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Nam, Taick Sang(남택상)
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