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뇌졸중 환자에서 Tizanidine의 경직치료 효과에 대한 정량적 평가
DC Field | Value | Language |
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dc.contributor.author | 김덕용 | - |
dc.contributor.author | 박창일 | - |
dc.date.accessioned | 2015-07-15T17:04:34Z | - |
dc.date.available | 2015-07-15T17:04:34Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 1225-584X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114176 | - |
dc.description.abstract | Objective: The aims of this study were to evaluate quantitatively the effect of tizanidine on spasticity reduction and to evaluate the effective and tolerable dosage of it in stroke patients. Method: A prospective, randomized controlled study was carried out. 24 stroke patients were included and randomly assigned to a control and experimental group. In experimental group, tizanidine was medicated from starting dose of 3 mg/day and titrated up by 3 mg/day increments every 3 days to a maximal dose of 15 mg/day. In both group assessment of spasticity was done by clinical and biomechanical-neurophysiological methods one day before medication (baseline), on 9th and 15th days after medication. Biomechenical-neurophysiological assessment was done through isokinetic dynamometer and BIOPAC system. Results: In control group, no significant changes were found in the degree of spasticity between each assessment. In experimental group, most of the parameters that determine the degree of spasticity revealed the significant reduction of spasticity on the post-medication assessment compared with the baseline assessment (p<0.01). The degree of spasticity reduction was increased with the increase of dosage. The incidence of adverse effect was also increased with the increase of dosage, but tolerable within the dosage of 15 mg/day. Conclusion: Tizanidine was effective in reducing spasticity in stroke patients. Its efficacy and adverse effects were dosage-related. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | Journal of the Korean Academy of Rehabilitation Medicine (대한재활의학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Muscle Spasticity/drug therapy* | - |
dc.subject.MESH | Muscle Spasticity/etiology | - |
dc.subject.MESH | Neuromuscular Diseases/complications | - |
dc.subject.MESH | Neuromuscular Diseases/drug therapy* | - |
dc.subject.MESH | Parasympatholytics/therapeutic use* | - |
dc.title | 뇌졸중 환자에서 Tizanidine의 경직치료 효과에 대한 정량적 평가 | - |
dc.title.alternative | Quantitative Assessment of the Effect of Tizanidine on Spasticity in Stroke Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Rehabilitation Medicine (재활의학) | - |
dc.contributor.googleauthor | 김덕용 | - |
dc.contributor.googleauthor | 박창일 | - |
dc.contributor.googleauthor | 박영선 | - |
dc.contributor.googleauthor | 나상일 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00375 | - |
dc.contributor.localId | A01717 | - |
dc.relation.journalcode | J01803 | - |
dc.identifier.pmid | 9826984 | - |
dc.subject.keyword | Quantifying spasticity | - |
dc.subject.keyword | Tizanidine | - |
dc.subject.keyword | Stroke | - |
dc.contributor.alternativeName | Kim, Deog Young | - |
dc.contributor.alternativeName | Park, Chang Il | - |
dc.contributor.affiliatedAuthor | Kim, Deog Young | - |
dc.contributor.affiliatedAuthor | Park, Chang Il | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 27 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 471 | - |
dc.citation.endPage | 479 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Academy of Rehabilitation Medicine (대한재활의학회지), Vol.27(4) : 471-479, 2003 | - |
dc.identifier.rimsid | 52050 | - |
dc.type.rims | ART | - |
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