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Orphanin FQ/nociceptin blocks methamphetamine place preference in rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김동구 | - |
dc.date.accessioned | 2015-07-15T17:02:26Z | - |
dc.date.available | 2015-07-15T17:02:26Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0959-4965 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114105 | - |
dc.description.abstract | Orphanin FQ/nociceptin (NOC) has been reported to regulate dopaminergic neurotransmission in rewarding pathway, and to suppress the development of conditioned place preference (CPP) induced by certain addictive drugs. In this study, we investigated the effect of NOC on CPP induced by repeated administration of methamphetamine (MAP) in rats. Repeated administration of MAP (1 mg/kg, i.p.) induced substantial CPP. MAP-induced CPP was completely suppressed by NOC (10 nmol, i.c.v.). Pretreatment with [Nphe1]nociceptin(1-13)NH2 (50 nmol, i.c.v.), an antagonist of the NOC receptor, antagonized the suppressive effect of NOC on MAP-induced CPP. These results suggest that NOC blocks MAP-induced CPP by activation of the NOC receptor. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 2383~2385 | - |
dc.relation.isPartOf | NEUROREPORT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Behavior, Addictive/drug therapy | - |
dc.subject.MESH | Behavior, Addictive/psychology | - |
dc.subject.MESH | Conditioning (Psychology)/drug effects* | - |
dc.subject.MESH | Conditioning (Psychology)/physiology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Methamphetamine/antagonists & inhibitors* | - |
dc.subject.MESH | Methamphetamine/pharmacology* | - |
dc.subject.MESH | Opioid Peptides/pharmacology* | - |
dc.subject.MESH | Opioid Peptides/therapeutic use | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.title | Orphanin FQ/nociceptin blocks methamphetamine place preference in rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Rong-Jie Zhao | - |
dc.contributor.googleauthor | Ran-Sook Woo | - |
dc.contributor.googleauthor | Kee-Won Kim | - |
dc.contributor.googleauthor | Dong-Goo Kim | - |
dc.contributor.googleauthor | Byoung-Soo Shin | - |
dc.contributor.googleauthor | Min-Suk Jeong | - |
dc.identifier.doi | 10.1097/01.wnr.0000095707.83808.2c | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00396 | - |
dc.relation.journalcode | J02361 | - |
dc.identifier.eissn | 1473-558X | - |
dc.identifier.pmid | 14663196 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-200312190-00019&LSLINK=80&D=ovft | - |
dc.subject.keyword | Conditioned place preference | - |
dc.subject.keyword | Methamphetamine | - |
dc.subject.keyword | Orphanin FQ/nociceptin | - |
dc.contributor.alternativeName | Kim, Dong Goo | - |
dc.contributor.affiliatedAuthor | Kim, Dong Goo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 14 | - |
dc.citation.number | 18 | - |
dc.citation.startPage | 2383 | - |
dc.citation.endPage | 2385 | - |
dc.identifier.bibliographicCitation | NEUROREPORT, Vol.14(18) : 2383-2385, 2003 | - |
dc.identifier.rimsid | 55718 | - |
dc.type.rims | ART | - |
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