126 210

Cited 12 times in

Receptors for Treponema pallidum Attachment to the Surface and Matrix Proteins of Cultured Human Dermal Microvascular Endothelial Cells

Authors
 Ju Hee Lee  ;  Hyun Joo Choi  ;  Kwang Hoon Lee  ;  Jung Bock Lee  ;  Min Geol Lee  ;  Jeanne Jung 
Citation
 YONSEI MEDICAL JOURNAL, Vol.44(3) : 371-378, 2003 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2003
MeSH
Carrier Proteins/physiology* ; Cell Membrane/metabolism ; Cells, Cultured ; Endothelium, Vascular/cytology ; Endothelium, Vascular/metabolism* ; Extracellular Matrix Proteins/metabolism* ; Humans ; Microcirculation ; Skin/blood supply* ; Treponema pallidum/physiology*
Keywords
t. pallidum ; RGD ; a5 integrin
Abstract
Pathogenicity of Treponema pallidum may depend upon the binding of Treponema pallidum to matrix proteins, especially to fibronectin. Infectious organism or cell to matrix interactions are mediated by a family of adhesion molecule receptors known as integrins. Once in the host, the pathogenic Treponema pallidumdum adheres to the vascular endothelium and readily penetrates surrounding tissues. Fibronectin plays an important role in the mediation of the attachment of Treponema pallidum to host cells, including endothelial cells. We found that the binding of Treponema pallidum to human dermal microvascular endothelial cells and to a glass surface coated with fibronectin is inhibited by the presence of arginine-glycine-aspartic acid (RGD), and analysis of the surface receptor revealed an antigenic similarity to an integrin molecule, namely α5. This ability to adhere to host endothelium and fibronectin is quite unique to T. pallidum among the treponemes, and may be a key pathogenic factor.
Files in This Item:
T200305423.pdf Download
DOI
10.3349/ymj.2003.44.3.371
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kwang Hoon(이광훈)
Lee, Min Geol(이민걸) ORCID logo https://orcid.org/0000-0001-7040-5335
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114101
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse