Constitutive phosphorylation of FKHR transcription factor as a prognostic variable in acute myeloid leukemia

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Authors: June-Won Cheong ; Ju In Eom ; Yoo Hong Min ; Yun Woong Ko ; Jee Sook Hahn ; Seung Tae Lee ; Ho-Young Maeng

MeSH: Acute Disease ; Adolescent ; Adult ; Aged ; Blotting, Western ; DNA-Binding Proteins/metabolism* ; Female ; Forkhead Box Protein O1 ; Forkhead Transcription Factors ; Gene Expression Regulation, Leukemic* ; Gene Expression Regulation, Neoplastic* ; Genes, Tumor Suppressor ; Glycogen Synthase Kinase 3/metabolism ; Glycogen Synthase Kinase 3 beta ; Humans ; Leukemia, Myeloid/metabolism* ; Leukemia, Myeloid/pathology ; Male ; Middle Aged ; PTEN Phosphohydrolase ; Phosphoric Monoester Hydrolases/metabolism ; Phosphorylation ; Prognosis ; Protein-Serine-Threonine Kinases* ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-akt ; Survival Rate ; Transcription Factors/metabolism* ; Tumor Suppressor Proteins/metabolism

Keywords: FKHR ; Acute myeloid leukaemia ; Constitutive phosphorylation ; Akt–PKB ; Prognosis

Abstract: The transcription factor FKHR, which is controlled by Akt–PKB signaling, is involved in regulating cell cycle progression and cell death. In this study, the phosphorylation of FKHR was observed in 45 (73.8%) of 61 patients with acute myeloid leukemia (AML). The phosphorylation of Akt–PKB was found to be significantly associated with phospho-FKHR (P<0.001). Patients with phospho-FKHR had a significantly shorter overall survival than those without (P<0.05). In conclusion, the constitutive phosphorylation of FKHR was observed in the majority of AML, and the detection of phospho-FKHR might provide a new tool for identifying AML patients with an unfavorable outcome.

Full Text: http://www.sciencedirect.com/science/article/pii/S0145212603001024

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

Yonsei Authors: Min, Yoo Hong(민유홍) https://orcid.org/0000-0001-8542-9583
Cheong, June-Won(정준원) https://orcid.org/0000-0002-1744-0921

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