Cited 49 times in
Effect of Recombinant Human Bone Morphogenetic Protein-4 with Carriers in Rat Calvarial Defects
DC Field | Value | Language |
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dc.contributor.author | 김종관 | - |
dc.contributor.author | 김창성 | - |
dc.contributor.author | 조규성 | - |
dc.contributor.author | 채중규 | - |
dc.contributor.author | 최성호 | - |
dc.date.accessioned | 2015-07-15T16:59:05Z | - |
dc.date.available | 2015-07-15T16:59:05Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0022-3492 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113993 | - |
dc.description.abstract | BACKGROUND: Bone morphogenetic proteins (BMPs) are being evaluated as candidates for periodontal and bone regenerative therapy. However, the research on recombinant human bone morphogenetic protein-4 (rhBMP-4) has been insufficient to evaluate its capacity to enhance bone formation and its carrier system. The purpose of this study was to evaluate the bone regenerative effect of rhBMP-4 delivered with an absorbable collagen sponge (ACS) or beta-tricalcium phosphate (beta-TCP). We also compared the potential of beta-TCP to that of ACS as a carrier system for rhBMP-4. METHODS: Eight-mm calvarial critical-sized defects were created in 100 male Sprague-Dawley rats. The animals were divided into 5 groups of 20 animals each. The defects were treated with rhBMP-4/ACS (rhBMP-4 at 0.05 mg/ml), rhBMP-4/beta-TCP (rhBMP-4 at 0.05 mg/ml), ACS alone, beta-TCP alone, or left untreated for surgical control. The rats were sacrificed at 2 or 8 weeks postsurgery, and the results were evaluated radiodensitometrically, histologically, and histomorphometrically. RESULTS: The results of radiodensitometric analysis were as follows: the rhBMP-4/ACS and the rhBMP-4/beta-TCP groups were more radiopaque than other groups at both 2 and 8 weeks (P < 0.01). The histologic observations were as follows: in the rhBMP-4/ACS and the rhBMP-4/beta-TCP groups, new bone was evident at the defect sites at 2 weeks and 8 weeks. The results of histomorphometric analysis were as follows: the rhBMP-4/ACS and the rhBMP-4/beta-TCP groups had more bone (%) than other groups at both 2 and 8 weeks (P < 0.01). CONCLUSIONS: Surgical implantation of rhBMP-4/ACS may be used to support bone regeneration in the rat calvarial critical-sized defect, and rhBMP-4/beta-TCP may be able to regenerate bone in the rat calvarial critical-sized defect without complication. In addition, both ACS and beta-TCP may be considered as available carriers for rhBMP-4. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 787~797 | - |
dc.relation.isPartOf | JOURNAL OF PERIODONTOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animal studies | - |
dc.subject.MESH | bone, craniofacial | - |
dc.subject.MESH | bone regeneration | - |
dc.subject.MESH | collagen/therapeutic use | - |
dc.subject.MESH | proteins, bone morphogenetic | - |
dc.subject.MESH | proteins recombinant | - |
dc.subject.MESH | tricalcium phosphate | - |
dc.title | Effect of Recombinant Human Bone Morphogenetic Protein-4 with Carriers in Rat Calvarial Defects | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Periodontology (치주과학) | - |
dc.contributor.googleauthor | Seong-Hee Ahn | - |
dc.contributor.googleauthor | Chang-Sung Kim | - |
dc.contributor.googleauthor | Kyoo-Sung Cho | - |
dc.contributor.googleauthor | Soo-Boo Han | - |
dc.contributor.googleauthor | Chong-Kwan Kim | - |
dc.contributor.googleauthor | Jung-Kiu Chai | - |
dc.contributor.googleauthor | Seong-Ho Choi | - |
dc.contributor.googleauthor | Yong-Jun Lee | - |
dc.contributor.googleauthor | Hun-Joo Suk | - |
dc.identifier.doi | 10.1902/jop.2003.74.6.787 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01041 | - |
dc.contributor.localId | A03810 | - |
dc.contributor.localId | A04024 | - |
dc.contributor.localId | A04081 | - |
dc.contributor.localId | A00914 | - |
dc.relation.journalcode | J01697 | - |
dc.identifier.eissn | 1943-3670 | - |
dc.identifier.pmid | 10.1902/jop.2003.74.6.787 | - |
dc.identifier.url | http://www.joponline.org/doi/abs/10.1902/jop.2003.74.6.787 | - |
dc.contributor.alternativeName | Kim, Chong Kwan | - |
dc.contributor.alternativeName | Kim, Chang Sung | - |
dc.contributor.alternativeName | Cho, Kyoo Sung | - |
dc.contributor.alternativeName | Chai, Jung Kyu | - |
dc.contributor.alternativeName | Choi, Seong Ho | - |
dc.contributor.affiliatedAuthor | Kim, Chang Sung | - |
dc.contributor.affiliatedAuthor | Cho, Kyoo Sung | - |
dc.contributor.affiliatedAuthor | Chai, Jung Kyu | - |
dc.contributor.affiliatedAuthor | Choi, Seong Ho | - |
dc.contributor.affiliatedAuthor | Kim, Chong Kwan | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 74 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 787 | - |
dc.citation.endPage | 797 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PERIODONTOLOGY, Vol.74(6) : 787-797, 2003 | - |
dc.identifier.rimsid | 54044 | - |
dc.type.rims | ART | - |
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