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Sevoflurane 흡입마취유도시 신속한 기관내 삽관을 위한 Rocuronium의 적정 용량

Other Titles
 Optimal Dose of Rocuronium for Rapid Tracheal Intubation under Sevoflurane Anesthesia 
 이행철  ;  양종윤  ;  신양식  ;  고신옥 
 Journal of Korean Society of Anesthesiologist (대한마취과학회지), Vol.44(5) : 598-604, 2003 
Journal Title
Journal of Korean Society of Anesthesiologist(대한마취과학회지)
Issue Date
Inhalation induction ; intubating dose ; rocuronium ; sevoflurane
Inhalation induction ; intubating dose ; rocuronium ; sevoflurane
Background : There are situations in anesthesia in which it may be desirable to achieve rapid tracheal intubation. Rapid tracheal intubation with rocuronium has been studied using a probability-based approach. But these studies used intravenous anesthetics for anesthetic induction. Therefore, we aimed to predict doses of rocuronium giving 90% and 95% probabilities of intubation within 60 seconds and to estimate their action durations using sevoflurane for anesthetic induction.
Methods : Anesthesia was induced in sixty patients with sevoflurane. Patients received randomly rocuronium, 0.0, 0.3, 0.6, 0.9 or 1.2 mg/kg (n = 12/dose). Laryngoscopy began 40 seconds later, aiming for intubation at 60 seconds, and conditions were graded as either perfect, acceptable of unacceptable, with the first two conditions being taken as
successful intubation. Duration of action was accepted as time until a twitch height recovery of 15%. The dose versus the fraction of patients showing successful intubation was analyzed by logistic regression. Doses giving 90% and 95% (D90 and D95) probabilities of successful intubation were calculated.
Results : Of the 12 patients in each group (0.0, 0.3, 0.6, 0.9 or 1.2 mg/kg), intubation was successful in 4, 10, 12, 12 and 12 patients, respectively. The D90 and D95 doses were determined to be 0.34 and 0.43 mg/kg, respectively.
Conclusions : After induction with sevoflurane, rocuronium at 0.43 mg/kg, gives a 95% probability of successful intubation at 60 seconds.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Koh, Shin Ok(고신옥)
Shin, Yang Sik(신양식)
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