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Landau-Kleffner 증후군의 임상적 고찰

Other Titles
 Clinical Reviews of Landau-Kleffner Syndrome 
Authors
 강훈철  ;  임인숙  ;  김흥동  ;  박상근  ;  황용순 
Citation
 Journal of the Korean Child Neurology Society (대한소아신경학회지), Vol.11(2) : 283-289, 2003 
Journal Title
 Journal of the Korean Child Neurology Society (대한소아신경학회지) 
ISSN
 1226-6884 
Issue Date
2003
MeSH
Landau-Kleffner syndrome
Keywords
Landau-Kleffner syndrome
Abstract
Purpose : We intended to describe the clinical features including characteristic etiologies, therapeutic approaches and outcomes for Landau-Kleffner syndrome(LKS). Methods : A retrospective chart reviews were done to reveal the clinical and electrophysiological features in 5 patients who were diagnosed as LKS and undergone extensive diagnostic work-up and various therapeutic interventions. Results : Among five LKS patients, 2 patients were males and 3 were females. All patients showed well controlled seizure outcomes but cognitive function including auditory and/or expressive aphasia were not improved in spite of using various anticonvulsants. Only two patients responded to steroid therapy but one patient showed repeated deterioration after discontinuation of the durg. Among 3 patients who were on ketogenic diet(KD), one patient showed a dramatic improvement in liguistic and cognitive functions in spite of underlying mitochondrial complex I deficiency. Multiple subpial transections (MST) were done in the other two patients because of incomplete recovery from ketogenic diet, and only one patient showed fairly successful improvement. Conclusion : Cognitive regression induced by LKS could be successfully improved by various therapeutic modalities including steroid, KD and palliative MST in most patients.
Full Text
http://scholar.dkyobobook.co.kr/searchDetail.laf?barcode=4010022735211
DOI
OAK-2003-00793
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113953
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