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유방암의 전신재발의 양상 및 전신재발 후 생존율에 영향을 미치는 인자

Other Titles
 The pattern of Sysetmic Failure and Factors Influencing on the Outcome after Distant Metastastasis in Breast Cancer 
 박경호  ;  김승일  ;  이경식  ;  박병우  ;  고승상 
 Journal of Korean Breast Cancer Society (한국유방암학회지), Vol.6(2) : 109-116, 2003 
Journal Title
 Journal of Korean Breast Cancer Society (한국유방암학회지) 
Issue Date
Metastatic breast cancer ; Axillary lymph node ; Micrometastasis ; Prognostic marker ; 전이성 유방암 ; 액와림프절 ; 미세전신전이 ; 예후인자
Metastatic breast cancer ; Axillary lymph node ; Micrometastasis ; Prognostic marker ; 전이성 유방암 ; 액와림프절 ; 미세전신전이 ; 예후인자
Purpose : Systemic failure after intial treatment of breast cancer is the most troublesome issue. To investigate the factors influencing on the outcome of metastatic breast cancer, this study was designed. Methods : Two hundred sixty-seven breast cancer patients with distant metastasis after initial treatment were included for this study. The patients showing confined metastasis to the ipsilateral supraclavicular lymph node, were excluded. Preferred sites of metastasis, intervals to distant metastasis, survival rates after systemic failure were investigated in association with clinico-pathological parameters. Student t-test, chi-square test and log-rank test were used for statistical analysis. Results : Patient age ranges from 20 to 71 years of age (mean 44.9). Forty-eight patients (18%) were initially included in stage 0 or I, 137 (51%) in stage Ⅱ, and 82% (31%) in stage Ⅲ. The preferred sites of metastasis were bone (47%), lung (29%), liver (9%), brain (8%) and multiple organs (4%) in descending order. Initial pathologic stage (P<0.001) and lymph node metastasis (P=0.016) were associated with the interval to distant metastasis, but, not the tumor size (P=0.246). Poor survival after systemic failure was associated with metastasis to the multiple organs or to liver (P<0.001), with no treatment after failure (P<0.001), and with failure within 3 years after initial treatment (P=0.056) Conclusion : Bone is the most prevalent metastatic site of breast cancer. Axillary lymph node status, especially the number of involved nodes, was associated with shorter disease free survival after initial treatment, which suggests that it might be a predictor of micrometastasis and a marker for an aggressive systemic treatment. Hepatic metastasis and metastasis to multiple organs was a poor prognostic marker of metastatic breast cancer. An aggressive systemic treatment after systemic failure might improve the survival.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Byeong Woo(박병우) ORCID logo https://orcid.org/0000-0003-1353-2607
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