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진행성 요로상피암에서 Gemcitabine과 Cisplatin 병합요법의 혈액학적 독성

Other Titles
 Hematologic Toxicity of Gemcitabine and Cisplatin Combination Therapy in Advanced Urothelial Cancer 
Authors
 장창식  ;  조진선  ;  정병수  ;  홍창희  ;  김성용  ;  양대열  ;  이영구  ;  이상곤 
Citation
 KOREAN JOURNAL OF UROLOGY, Vol.44(7) : 672-676, 2003 
Journal Title
KOREAN JOURNAL OF UROLOGY(대한비뇨기과학회지)
ISSN
 0494-4747 
Issue Date
2003
MeSH
Gemcitabine ; Carcinoma ; transitional cell ; Toxicity ; Hematology
Keywords
Gemcitabine ; Carcinoma ; transitional cell ; Toxicity ; Hematology
Abstract
PURPOSE: To evaluate the hematologic toxicity of gemcitabine and cisplatin (GC) in patients with advanced transitional cell carcinomas. MATERIALS AND METHODS: From 25 patients, with advanced transitional cell carcinomas, 8 had previously received M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) chemotherapy for a metastatic disease, and were scheduled to receive gemcitabine, 1,000mg/m2, intravenously, over 30 minutes, on days 1, 8 and 15, and cisplatin, 70mg/m2, over 1 hour, on day 2 of a 28-day cycle. The hematological toxicities of each cycle were evaluated. RESULTS: The main hematological toxicities were thrombocytopenia (grade 3 in 24% and grade 4 in 16% of patients), leukopenia (grade 3 in 14% of patients) and anemia (grade 3 in 12% of patients). Four of the patients that experienced grade 4 thrombocytopenia had a tendency for recurring grade 4 thrombocytopenia during the GC chemotherapy. However, there was no evidence of bleeding. CONCLUSIONS: The most severe hematological toxicity of the GC chemotherapy was thrombocytopenia. The careful observation of the patients that experience grade 4 thrombocytopenia is recommended.
Files in This Item:
T200304603.pdf Download
DOI
OAK-2003-00730
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Hong, Chang Hee(홍창희) ORCID logo https://orcid.org/0000-0002-0946-7702
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113890
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