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진행성 요로상피암에서 Gemcitabine과 Cisplatin 병합요법의 혈액학적 독성
DC Field | Value | Language |
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dc.contributor.author | 홍창희 | - |
dc.date.accessioned | 2015-07-15T16:56:02Z | - |
dc.date.available | 2015-07-15T16:56:02Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0494-4747 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113890 | - |
dc.description.abstract | PURPOSE: To evaluate the hematologic toxicity of gemcitabine and cisplatin (GC) in patients with advanced transitional cell carcinomas. MATERIALS AND METHODS: From 25 patients, with advanced transitional cell carcinomas, 8 had previously received M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) chemotherapy for a metastatic disease, and were scheduled to receive gemcitabine, 1,000mg/m2, intravenously, over 30 minutes, on days 1, 8 and 15, and cisplatin, 70mg/m2, over 1 hour, on day 2 of a 28-day cycle. The hematological toxicities of each cycle were evaluated. RESULTS: The main hematological toxicities were thrombocytopenia (grade 3 in 24% and grade 4 in 16% of patients), leukopenia (grade 3 in 14% of patients) and anemia (grade 3 in 12% of patients). Four of the patients that experienced grade 4 thrombocytopenia had a tendency for recurring grade 4 thrombocytopenia during the GC chemotherapy. However, there was no evidence of bleeding. CONCLUSIONS: The most severe hematological toxicity of the GC chemotherapy was thrombocytopenia. The careful observation of the patients that experience grade 4 thrombocytopenia is recommended. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | KOREAN JOURNAL OF UROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Gemcitabine | - |
dc.subject.MESH | Carcinoma | - |
dc.subject.MESH | transitional cell | - |
dc.subject.MESH | Toxicity | - |
dc.subject.MESH | Hematology | - |
dc.title | 진행성 요로상피암에서 Gemcitabine과 Cisplatin 병합요법의 혈액학적 독성 | - |
dc.title.alternative | Hematologic Toxicity of Gemcitabine and Cisplatin Combination Therapy in Advanced Urothelial Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨기과학) | - |
dc.contributor.googleauthor | 장창식 | - |
dc.contributor.googleauthor | 조진선 | - |
dc.contributor.googleauthor | 정병수 | - |
dc.contributor.googleauthor | 홍창희 | - |
dc.contributor.googleauthor | 김성용 | - |
dc.contributor.googleauthor | 양대열 | - |
dc.contributor.googleauthor | 이영구 | - |
dc.contributor.googleauthor | 이상곤 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04447 | - |
dc.relation.journalcode | J02135 | - |
dc.subject.keyword | Gemcitabine | - |
dc.subject.keyword | Carcinoma | - |
dc.subject.keyword | transitional cell | - |
dc.subject.keyword | Toxicity | - |
dc.subject.keyword | Hematology | - |
dc.contributor.alternativeName | Hong, Chang Hee | - |
dc.contributor.affiliatedAuthor | Hong, Chang Hee | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 44 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 672 | - |
dc.citation.endPage | 676 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF UROLOGY, Vol.44(7) : 672-676, 2003 | - |
dc.identifier.rimsid | 41465 | - |
dc.type.rims | ART | - |
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