200 481

Cited 0 times in

소아 IgA 신병증의 예후와 관련한 임상병리학적 고찰

Other Titles
 A Clinicopathologipal Study on the Prognosis of IgA Nephropathy in Children 
Authors
 권재훈  ;  최은나  ;  이재승  ;  정현주  ;  박지민 
Citation
 Journal of the Korean Society of Pediatric Nephrology (대한소아신장학회지), Vol.7(1) : 23-29, 2003 
Journal Title
Journal of the Korean Society of Pediatric Nephrology(대한소아신장학회지)
ISSN
 1226-5292 
Issue Date
2003
MeSH
IgA nephropathy ; Adverse events ; Prognosis
Keywords
IgA nephropathy ; Adverse events ; Prognosis
Abstract
Purpose: This study was performed to determine the natural history of histologlcalIy confirmed IgA nephropathy in pediatric patients who presented with hematuria and proteinuria.
Patients and Methods : We reviewed the clinical course of 57 patients diagnosed with IgA nephropathy at the age of 15 years or younger from 1981 to 2000. All patients presented with hematuria or minimal proteinuria(<40 mg/m²/day) and had normal renal function and blood pressure at the time of renal biopsy. Based on the clinical and pathological findings at the time of diagnosis, we sought for complications of IgA nephropathy such as heavy proteinuria(≥40 mg/m²/day), hypertension, chronic renal failure.
Results : The mean age at presentation was 9.5±2.8 years(4 to 15 years) and 42(74%) were male. Isolated gross hematuria was observed in 20 patients(35%), microscopic hematuria in 3(5%), minimal proteinuria in 4(7%), both gross hematuria and minimal proteinuria in 15(26%), and both microscopic hematuria and minimal proteinuria in 15(26%). During a median follow-up of 7.0±3.5 years, 38(67%) had complete resolution of hematuria and proteinuria, 12(21%) had persistently abnormal urinalysis without development of adverse events. Only 7(12%) developed adverse events : 4(7%) developed severe proteinuria, 1(2%) became hypertensive, and 2(3%) developed impaired renal function. By univariate analysis using the chisquare test, the age at presentation(>10 years)(P<0.01) and poor histological classes of the Lee or Haas classification at onset(P<0.05) were significantly correlated with adverse events, whereas sex and clinical signs at onset were less concordant.
Conclusion : We can conclude that the prognosis of IgA nephropathy diagnosed In early childhood is better and a good correlation exists between the clinical manifestations of this disease and the histological classes.
Files in This Item:
T200304240.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Jeong, Hyeon Joo(정현주) ORCID logo https://orcid.org/0000-0002-9695-1227
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113789
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links