2 140

Cited 39 times in

Prior airway exposure to allergen increases virus-induced airway hyperresponsiveness

 Mika J Mäkelä Ralph Tripp  ;  Azzeddine Dakhama  ;  Erwin W Gelfand  ;  Larry J Anderson  ;  Matti Waris  ;  Anthony Joetham  ;  Toshihide Ikemura  ;  Jun-Won Park 
 Journal of Allergy and Clinical Immunology, Vol.112(5) : 861-869, 2003 
Journal Title
 Journal of Allergy and Clinical Immunology 
Issue Date
Administration, Inhalation ; Animals ; Bronchial Hyperreactivity/physiopathology* ; Bronchial Hyperreactivity/virology* ; Cytokines/biosynthesis ; Female ; Lung/metabolism ; Lung/pathology ; Lymphocytes/metabolism ; Lymphocytes/pathology ; Mice ; Mice, Inbred BALB C ; Ovalbumin/administration & dosage ; Ovalbumin/immunology* ; Pneumonia, Viral/etiology ; Pneumonia, Viral/pathology ; Respiratory Syncytial Virus Infections/complications* ; Respiratory Syncytial Virus Infections/pathology ; Respiratory System/immunology*
Airway hyperresponsiveness ; asthma ; allergen ; viral infection ; T lymphocytes ; cytokines
BACKGROUND: Respiratory syncytial virus (RSV) bronchiolitis in early life can lead to changes in airway function, but there are likely additional predisposing factors, such as prior allergen exposure, determining which children develop wheezing and asthma. OBJECTIVE: To define the effects of prior airway exposure to sensitizing allergen on the development of airway inflammation and hyperresponsiveness (AHR) to subsequent RSV infection. METHODS: BALB/c mice were exposed to ovalbumin or PBS exclusively through the airways and subsequently infected with RSV or sham-inoculated. AHR, lung inflammation, and the frequency of cytokine-producing T lymphocytes in the lung were determined. RESULTS: In PBS-exposed mice, RSV infection induced AHR and an increased proportion of TH1-type (IFN-gamma and IL-12) cytokine-producing cells in the lungs. However, in mice previously exposed to ovalbumin through the airways and subsequently infected with RSV, the degree of AHR was significantly increased and was associated with an increased proportion of TH2 (IL-4, IL-5) cytokine-producing T lymphocytes. This response was also associated with an increased accumulation of eosinophils, neutrophils, and CD8+ T cells in the lungs. CONCLUSIONS: These data suggest that prior airway exposure to allergen may predispose sensitized hosts to a greater degree of altered airway function upon subsequent respiratory viral infection.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jung Won(박중원) ORCID logo https://orcid.org/0000-0003-0249-8749
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.