2480 403

Cited 0 times in

소아 말초 CD 34 양성 세포의 가동화 채집에 관한 예측인자 분석

Other Titles
 Predictive parameters for mobilized peripheral blood CD34+ progenitor cell collection in pediatric patients 
 함태영  ;  김정훈  ;  유철주  ;  원성철 
 대한조혈모세포이식학회지, Vol.8(1) : 31-36, 2003 
Journal Title
Issue Date
BACKGROUND: In children, it is very important to decide the optimum time to collect the peripheral blood stem cell (PBSC). So, we analyzed several predictive parameters for the yield of PBSC mobilization. METHODS: We analyzed data from 19 patients who underwent 31 stem cell mobilization episodes and 44 leukapheresis procedures, retrospectively. In this study, CD34+ cells, total white blood cells (WBC), and monocyte counts in peripheral blood (PB) on the harvest day were used for analyses. Increment of WBC and monocyte count from nadir to harvest day, and [increment of WBC count from nadir to harvest day (deltaWBC)]/[duration from nadir to harvest day (deltaT)], [increment of monocyte count from nadir to harvest day (delta MONO)]/[deltaT] were also analyzed as predictive parameters for the yield of progenitor cell mobilization. RESULTS: Linear regression analysis revealed a strong correlation between CD34+ cell value in PB on the harvest day and the number of CD34+ cells collected (R=0.72, P=0.001). WBC counts in PB on the harvest day, and increment of WBC count did not correlate with collected CD34+ cells. The yield of PBSC mobilization showed significant correlation with monocyte counts on the harvest day (R=0.314, P=0.038), deltaMONO (R=0.302, P=0.046), deltaWBC/deltaT (R=0.417, P=0.005) and deltaMONO/deltaT (R=0.342, P=0.023). CONCLUSION: results suggested that the PBSC yield in pediatric patients could be predicted from the measurement of circulating CD34+ cell concentration on the day of collection, which was consistent with previous data. In this study, we found other several predictive parameters for the yield of peripheral blood stem cell mobilization. Measurement of pre-apheresis peripheral blood CD34+ cell, monocyte counts, the increment of monocyte counts, deltaWBC/deltaT, and deltaMONO/deltaT might be particularly useful in determining the optimum time to start PBSC collection in pediatric patients.
Files in This Item:
T200303843.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.