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원발성 피부 CD30 양성 대형세포 림프종 8예에 대한 임상 및 조직학적 관찰

Other Titles
 Clinicopathologic Study of 8 Cases of Primary Cutaneous CD30-positive Cutaneous Large Cell Lymphoma 
Authors
 김유찬  ;  이민걸  ;  서기석  ;  양우익  ;  박상건 
Citation
 Korean Journal of Dermatology (대한피부과학회지), Vol.41(11) : 1471-1477, 2003 
Journal Title
Korean Journal of Dermatology(대한피부과학회지)
ISSN
 0494-4739 
Issue Date
2003
MeSH
Primary cutaneous CD30-positive large cell lymphoma
Keywords
Primary cutaneous CD30-positive large cell lymphoma
Abstract
Background : Although several cases of primary cutaneous CD3O-positive large cell lymphoma have been reported, immunohistochemical study on the tumor has not been reported in Korea. Objective : Our purpose is to evaluate the clinicopathologic and immunohistochemical findings of primary cutaneous CD3O-positive large cell lymphoma. Methods : An immunohistochemical study was performed on paraffin sections of 8 primary cutaneous CD3O-positive large cell lymphoma using CD3, CD45RO, CD45, CD2O, CD3O, and epithelial membrane antigen(EMA). Results : 1. Primary cutaneous CD3O-positive large cell lymphoma occurred equally on males and females. The average age of the patients was 49. The lesion occurred most commonly as nodules on the extremities. Spontaneous regression occurred in 3 cases. The most common treatment was radiotherapy. 2. Histopathologically, 2 of 8 cases showed epidermal hyperplasia with intraepidermal neutrophils. Epidermotropism was found focally in 1 case. Inflammatory cells were present at the periphery of the lesions in 2 cases, but they were admixed with the large atypical cells in 1 case. Tumor cells invaded the subcutaneous tissue in 4 of 6 cases. 3. Immunohistochemically, the large anaplastic cells showed CD3O positivity. Tumor cells in all cases showed positivity for CD3, CD45RO, and CD45, but negative for CD2O. Tumor cells stained with EMA in 1 of 6 cases. Conclusion : Primary cutaneous CD3O-positive large cell lymphoma showed immunophenotype of T-cell lymphoma. It showed some clinicopathologic features of lymphomatoid papulosis, which suggests that both entities represent 2 ends(malignant and benign) of a spectrum of CD3O-positive lymphoproliferative disorders. Therefore, for the diagnosis of primary cutaneous CD3O-positive large cell lymphoma, all clinicopathologic and immunohistochemical findings should be considered together.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Lee, Min Geol(이민걸) ORCID logo https://orcid.org/0000-0001-7040-5335
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113670
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