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Altered hemispheric asymmetry and positive symptoms in schizophrenia: equivalent current dipole of auditory mismatch negativity

Authors
 Tak Youn  ;  Hae-Jeong Park  ;  Jun Soo Kwon  ;  Myung Sun Kim  ;  Jae-Jin Kim 
Citation
 SCHIZOPHRENIA RESEARCH, Vol.59(2-3) : 253-260, 2003 
Journal Title
 SCHIZOPHRENIA RESEARCH 
ISSN
 0920-9964 
Issue Date
2003
MeSH
Adult ; Antipsychotic Agents/therapeutic use ; Auditory Perceptual Disorders/diagnosis ; Auditory Perceptual Disorders/etiology* ; Chlorpromazine/therapeutic use ; Cognition Disorders/diagnosis ; Cognition Disorders/etiology ; Electroencephalography ; Evoked Potentials, Auditory/physiology* ; Female ; Functional Laterality/physiology* ; Hallucinations/diagnosis ; Hallucinations/etiology ; Humans ; Magnetic Resonance Imaging ; Male ; Schizophrenia/complications ; Schizophrenia/drug therapy ; Schizophrenia/physiopathology* ; Temporal Lobe/abnormalities* ; Temporal Lobe/physiopathology*
Keywords
Mismatch negativity ; Equivalent current dipole ; Hallucination ; Positive symptom ; Schizophrenia
Abstract
The abnormality of mismatch negativity (MMN) in schizophrenia is thought to be associated with perceptional disturbance and cognitive dysfunction. The purpose of the present study was to investigate the change of the normal functional hemispheric lateralization in schizophrenia by employing the equivalent current dipole (ECD) model of auditory MMN with individual MRI and high-density electroencephalography (EEG). The MMNs resulting from auditory stimuli with passive oddball paradigm in a group of schizophrenics (n=15), and also a group of age-, sex-, and handedness-matched normal controls, were recorded by 128 channel EEG. The location and power of ECD sources at the peak point were calculated. Individual 3-D brain magnetic resonance images (MRI) were used for realistic head modeling and for source localization. For both groups, the MMN source was determined to be located in the superior temporal gyrus (STG). However, the normal functional hemispheric asymmetry of ECD power was significantly altered in the schizophrenics (χ2 test=16.13, p<0.001). Left MMN ECD power and the asymmetry coefficient (AC) were negatively correlated with the positive scores from Positive and Negative Syndrome Scale (PANSS) (r=−0.673, p=0.008), especially with the hallucinatory behavior subscale (r=−0.677, p=0.008). These findings support the deficits in preattentive automatic processing of auditory stimuli, especially in the left hemisphere, and indicate the correlation between positive symptoms, especially auditory hallucination, and left temporal lobe dysfunction in schizophrenia.
Full Text
http://www.sciencedirect.com/science/article/pii/S0920996402001548
DOI
10.1016/S0920-9964(02)00154-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113623
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