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Identification of Baseline Clinical Factors Which Predict Medical Treatment Failure of Benign Prostatic Hyperplasia: An Observational Cohort Study

Authors
 Sung Joon Hong  ;  Woo Jin Ko  ;  Byung Ha Chung  ;  Sun Il Kim 
Citation
 EUROPEAN UROLOGY, Vol.44(1) : 94-100, 2003 
Journal Title
EUROPEAN UROLOGY
ISSN
 0302-2838 
Issue Date
2003
MeSH
Adrenergic alpha-Antagonists/administration & dosage* ; Aged ; Aged, 80 and over ; Biopsy, Needle ; Cohort Studies ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug Therapy, Combination ; Finasteride/administration & dosage* ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Proportional Hazards Models ; Prostatic Hyperplasia/drug therapy* ; Prostatic Hyperplasia/pathology* ; Risk Assessment ; Severity of Illness Index ; Treatment Failure ; Urinary Retention/diagnosis ; Urodynamics
Keywords
Benign prostatic hyperplasia ; Treatment failure ; Prostate volume ; IPSS
Abstract
OBJECTIVE: The aim of this study was to identify the clinical baseline factors that affect the long-term treatment failure of benign prostatic hyperplasia (BPH). METHODS: 437 men over 50 years of age with BPH were enrolled for this analysis. Patients were allocated to a medication and a surgical treatment (following medication) group. We initially examined the International Prostatic Symptom Score (IPSS), uroflow rate, prostate volume, postvoid residual volume, and the serum prostate specific antigen level as clinical baseline factors and analyzed differences between the two groups. RESULTS: 337 patients (77.1%) were given maintenance medical treatment during follow-up, and 100 patients (22.9%) had surgical treatment following medication. Statistically significant differences were found in IPSS and prostate volume between the surgical and medication groups (IPSS: 22.6+/-6.4 vs. 18.7+/-5.8, prostate volume (cm(3)): 36.3+/-14.4 vs. 30.1+/-11.0, respectively). According to the ROC curve-based prediction of the failure for medical therapy, the best cutoff values of IPSS and prostate volume were 21 (area under ROC curve: 0.67) and 32cm(3) (area under ROC curve: 0.65), respectively. CONCLUSIONS: The results show that BPH patients with more severe IPSS and larger prostate volume have a higher risk of medical treatment failure, and suggest that the IPSS and prostate volume may be useful predictors of medical treatment maintenance.
Full Text
http://www.sciencedirect.com/science/article/pii/S0302283803001994
DOI
10.1016/S0302-2838(03)00199-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Chung, Byung Ha(정병하) ORCID logo https://orcid.org/0000-0001-9817-3660
Hong, Sung Joon(홍성준) ORCID logo https://orcid.org/0000-0001-9869-065X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113599
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