Cited 28 times in
Systemic 5-hydroxy-l-tryptophan down-regulates the arcuate CART mRNA level in rats
DC Field | Value | Language |
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dc.contributor.author | 김동구 | - |
dc.date.accessioned | 2015-07-15T16:46:25Z | - |
dc.date.available | 2015-07-15T16:46:25Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0167-0115 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113571 | - |
dc.description.abstract | This study was conducted to determine if serotonin (5-hydroxytryptamine; 5-HT) system correlates with the hypothalamic expression of cocaine-amphetamine-regulated transcript (CART) gene. Rats received intraperitoneal 5-hydroxy-l-tryptophan (5-HTP; a single or three daily injections at a dose of 100 mg/kg/10 ml), and CART mRNA level in the hypothalamus was examined by in situ hybridization at different time points. The 5-HT contents of the hypothalamus as well as the brainstem was increased persistently by 5-HTP injections, and food intake and body weight gain reduced. CART mRNA level decreased significantly in the hypothalamic arcuate nucleus by three daily 5-HTP, but not by a single injection. The pair-fed group of the chronic 5-HTP did not show a decrease in the arcuate CART mRNA level. The plasma leptin level markedly decreased in the chronic 5-HTP group, compared to the saline group, however, still higher than the pair-fed group with a statistical significance. These results suggest that 5-HT may suppress CART mRNA expression in the arcuate nucleus, not only by leptin signaling via its anorectic effect on the control of food intake, but also by some non-leptin mediated pathway. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 73~80 | - |
dc.relation.isPartOf | REGULATORY PEPTIDES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Gene expression | - |
dc.subject.MESH | Hypothalamus | - |
dc.subject.MESH | Serotonin | - |
dc.subject.MESH | Leptin | - |
dc.title | Systemic 5-hydroxy-l-tryptophan down-regulates the arcuate CART mRNA level in rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Si Ho Choi | - |
dc.contributor.googleauthor | Bum Sup Kwon | - |
dc.contributor.googleauthor | Jeong Won Jahng | - |
dc.contributor.googleauthor | Dong Goo Kim | - |
dc.contributor.googleauthor | Hoon Taek Lee | - |
dc.contributor.googleauthor | Thomas A. Houpt | - |
dc.contributor.googleauthor | Seoul Lee | - |
dc.identifier.doi | 10.1016/S0167-0115(03)00126-5 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00396 | - |
dc.relation.journalcode | J02602 | - |
dc.identifier.eissn | 1873-1686 | - |
dc.identifier.pmid | 10.1016/S0167-0115(03)00126-5 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0167011503001265 | - |
dc.subject.keyword | Gene expression | - |
dc.subject.keyword | Hypothalamus | - |
dc.subject.keyword | Serotonin | - |
dc.subject.keyword | Leptin | - |
dc.contributor.alternativeName | Kim, Dong Goo | - |
dc.contributor.affiliatedAuthor | Kim, Dong Goo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 115 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 73 | - |
dc.citation.endPage | 80 | - |
dc.identifier.bibliographicCitation | REGULATORY PEPTIDES, Vol.115(2) : 73-80, 2003 | - |
dc.identifier.rimsid | 52221 | - |
dc.type.rims | ART | - |
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