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Therapeutic effect of recombinant human erythropoietin on anaemia with erythropoietin deficiency in diabetic patients

Authors
 D. J. Kim  ;  Y. M. Kim  ;  H. C. Lee  ;  K. B. Huh  ;  J. S. Hahn  ;  K. R. Kim  ;  S. K. Lim  ;  Y. D. Song  ;  B. S. Cha  ;  C. W. Ahn  ;  Y. S. Yun 
Citation
 DIABETIC MEDICINE, Vol.20(8) : 661-664, 2003 
Journal Title
 DIABETIC MEDICINE 
ISSN
 0742-3071 
Issue Date
2003
MeSH
Anemia/drug therapy* ; Diabetes Complications* ; Erythropoietin/deficiency* ; Erythropoietin/therapeutic use* ; Female ; Humans ; Male ; Middle Aged ; Recombinant Proteins
Keywords
anaemia ; erythropoietin ; diabetic nephropathy ; recombianant erythropoietin
Abstract
AIMS: The aim of this study was to investigate the therapeutic effect of recombinant human erythropoietin (rHuEpo) on anaemia with erythropoietin deficiency in diabetic patients. METHODS: Twenty diabetic patients with anaemia and Epo deficiency were enrolled. All patients were treated with rHuEpo (Epokine; 4000 U/day s.c., three times a week) for 8 weeks. RESULTS: The responder group (n = 14) had significant increments in haemoglobin compared with the non-responder group (n = 6) (P < 0.05). No significant differences were found between the responder and non-responder groups in terms of duration of diabetes mellitus, serum creatinine level, 24-h urine albumin excretion rates, frequency of diabetic microangiopathy, or HbA1c. There was no difference between the two groups in terms of serum iron and total iron-binding capacity (TIBC). Serum ferritin level was significantly higher in the responder group than in the non-responder group (240.3 +/- 108.4, 25.8 +/- 3.0 micro g/l, P < 0.05), as was transferrin saturation (32.7 +/- 7.9%, 21.2 +/- 5.3%, P < 0.05). CONCLUSIONS: rHuEpo could be useful in the treatment of anaemia with erythropoietin deficiency in diabetic patients, and the degree of iron storage and functional iron deficiency might be the main cause of hyporesponsiveness to rHuEpo.
Full Text
http://onlinelibrary.wiley.com/doi/10.1046/j.1464-5491.2003.01012.x/abstract
DOI
10.1046/j.1464-5491.2003.01012.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113553
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