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신우요관이행부 협착에서 보상성 사구체비후는 신주사상 Supranormal 분리신기능의 원인이 아니다

Other Titles
 Compensatory Glomerular Hypertrophy is not a Cause of Supranormal Renographic Differential Renal Function in Patients with Ureteropelvic Junction Obstruction. 
 함원식  ;  정현주  ;  한상원 
 KOREAN JOURNAL OF UROLOGY, Vol.44(1) : 34-39, 2003 
Journal Title
Issue Date
Supranormal differential renal function ; Ureteropelvic junction obstruction ; Renal scan ; Glomerular hypertrophy
Supranormal differential renal function ; Ureteropelvic junction obstruction ; Renal scan ; Glomerular hypertrophy
Purpose: Increasing clinical importance is being placed on the role of differential renal function(DRF) for the management of congenital ureteropelvic junction obstructions. Supranormal DRF of a hydronephrotic kidney, on a renal scan, is hypothesized to be due to an increase in single nephron filtration or nephron volume. However, the etiology of this paradoxical phenomenon still remains to be elucidated. We studied the histopathological changes of hydronephrotic kidneys with a supranormal DRF. Materials and Methods: 35 children with unilateral congenital hydronephrosis and supranormal DRF(>55%), on preoperative renal scans, who had undergone pyeloplasty, were retrospectively evaluated. There were 3 female and 32 male patients. The mean age at the time of the operation was 12.6 months, ranging from 0.1 to 144 months. Needle biopsies, from 3 different sites at the lower pole of the kidney, were performed during surgery. To evaluate the presence of glomerular hypertrophy, the maximal planar area of the glomeruli was measured under light microscopy. Tissue samples were obtained in same manner from kidneys with no history of urinary tract disease on autopsy, and used as controls. The mean glomerular areas of the patient and control groups were plotted according to the patient's age. Results: The mean glomerular area in the patient group was smaller than in the control group, with the exception of 4 patients. According to the logistical regression, the probability of larger renal glomeruli increased with decreasing DRF(p=0.1155). Conclusions: The glomerular area of a hydronephrotic kidney, with a supranormal renal function on a renal scan, was not significantly larger than the normal controls. Therefore, we believe that the theory of increased nephron volume as a cause of a supranormal DRF can be excluded.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Jeong, Hyeon Joo(정현주) ORCID logo https://orcid.org/0000-0002-9695-1227
Han, Sang Won(한상원) ORCID logo https://orcid.org/0000-0003-0941-1300
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