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Functional Disconnection Between the Prefrontal and Parietal Cortices During Working Memory Processing in Schizophrenia: A [15O]H2O PET Study

Authors
 Jae-Jin Kim  ;  Jun Soo Kwon  ;  Myung Chul Lee  ;  Dong Soo Lee  ;  Myung Sun Kim  ;  Do Hyung Kang  ;  Tak Youn  ;  Hae Jeong Park 
Citation
 AMERICAN JOURNAL OF PSYCHIATRY, Vol.160(5) : 919-923, 2003 
Journal Title
 AMERICAN JOURNAL OF PSYCHIATRY 
ISSN
 0002-953X 
Issue Date
2003
MeSH
Adult ; Female ; Functional Laterality/physiology ; Humans ; Male ; Memory/physiology* ; Neural Pathways/diagnostic imaging ; Neural Pathways/physiopathology* ; Neuropsychological Tests ; Oxygen Radioisotopes ; Parietal Lobe/blood supply ; Parietal Lobe/diagnostic imaging ; Parietal Lobe/physiopathology* ; Prefrontal Cortex/blood supply ; Prefrontal Cortex/diagnostic imaging ; Prefrontal Cortex/physiopathology* ; Psychomotor Performance/physiology ; Regional Blood Flow ; Schizophrenia/diagnosis* ; Schizophrenia/diagnostic imaging ; Schizophrenia/physiopathology ; Tomography, Emission-Computed* ; Water
Keywords
12727696
Abstract
OBJECTIVE: The prefrontal-parietal circuits have been reported to play an important role in working memory. The purpose of this study was to use direct neuroimaging to address whether interregional correlation in the prefrontal-parietal circuits is impaired in schizophrenia. METHOD: [(15)O]H(2)O positron emission tomography was used to compare regional blood flow changes in 12 schizophrenic and 12 healthy comparison subjects during the n-back sequential-picture working memory task. Interregional correlation was assessed by correlating the regional activation of the lateral prefrontal area with that of other activated areas in each subject group. RESULTS: Dorsolateral prefrontal activation was observed around the right superior frontal sulcus in the healthy subjects, and ventrolateral prefrontal activation below the right inferior frontal sulcus was observed in the schizophrenic patients. Activation in the right lateral prefrontal cortex was significantly correlated with activation in the bilateral inferior parietal region in the healthy subjects but was not correlated with any regional activation in the patients. CONCLUSIONS: The findings suggest prefrontal-parietal functional disconnection, particularly prefrontal dissociation and abnormal prefrontal-parietal interaction, during working memory processing in schizophrenia.
Full Text
http://ajp.psychiatryonline.org/article.aspx?articleid=176213
DOI
10.1176/appi.ajp.160.5.919
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113460
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