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Correlation between midthigh low-density muscle and insulin resistance in obese nondiabetic patients in Korea

Authors
 Dolmi Kim  ;  Suyoun Nam  ;  Kapbum Huh  ;  Hyunchul Lee  ;  Kyungrae Kim  ;  Sungkil Lim  ;  Bongsoo Cha  ;  Junuh Kim  ;  Soojee Yoon  ;  Kyungwook Kim  ;  Chulwoo Ahn 
Citation
 DIABETES CARE, Vol.26(6) : 1825-1830, 2003 
Journal Title
DIABETES CARE
ISSN
 0149-5992 
Issue Date
2003
MeSH
Abdomen ; Adipose Tissue/anatomy & histology* ; Adipose Tissue/diagnostic imaging ; Adult ; Fasting ; Fatty Acids, Nonesterified/blood ; Female ; Glucose Intolerance/blood ; Humans ; Insulin Resistance/physiology* ; Korea ; Life Style ; Male ; Middle Aged ; Muscle, Skeletal/anatomy & histology* ; Muscle, Skeletal/diagnostic imaging ; Obesity/physiopathology* ; Postmenopause ; Premenopause ; Regression Analysis ; Skin ; Thigh ; Tomography, X-Ray Computed
Keywords
12766117
Abstract
OBJECTIVE:
We investigated the link between lipid-rich skeletal muscle, namely low-density muscle, and insulin resistance in Korea.
RESEARCH DESIGN AND METHODS:
Abdominal adipose tissue areas and midthigh skeletal muscle areas of 75 obese nondiabetic subjects (23 men, 52 women; mean age +/- SD, 41.9 +/- 14.1 years) were measured by computed tomography (CT). The midthigh skeletal muscle areas were subdivided into low-density muscle (0 to +30 Hounsfield units) and normal-density muscle (+31 to +100 Hounsfield units). The homeostasis model assessment (HOMA) score was calculated to assess whole-body insulin sensitivity.
RESULTS:
The abdominal visceral fat area and the midthigh low-density muscle area were found to be well correlated with the HOMA score (r = 0.471, P < 0.01 and r = 0.513, P < 0.01, respectively). The correlation between low-density muscle area and insulin resistance persisted after adjusting for BMI or total body fat mass (r = 0.451, P < 0.01 and r = 0.522, P < 0.01, respectively) and even after adjusting for abdominal visceral fat area (r = 0.399, P < 0.01).
CONCLUSIONS:
The midthigh low-density muscle area seems to be a reliable determinant of insulin resistance in Korean obese nondiabetic patients.
Full Text
http://care.diabetesjournals.org/content/26/6/1825.long
DOI
10.2337/diacare.26.6.1825
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113451
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