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Vitamin C intake and risk of ischemic heart disease in a population with a high prevalence of smoking

Authors
 Chung Mo Nam  ;  Kyung Won Oh  ;  Il Suh  ;  Won Heum Shim  ;  Seung Yun Cho  ;  Sun Ha Jee  ;  Kang Hee Lee 
Citation
 JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, Vol.22(5) : 372-378, 2003 
Journal Title
 JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION 
ISSN
 0731-5724 
Issue Date
2003
MeSH
Antioxidants/administration & dosage* ; Ascorbic Acid/administration & dosage* ; Case-Control Studies ; Confidence Intervals ; Feeding Behavior ; Humans ; Korea/epidemiology ; Male ; Middle Aged ; Multivariate Analysis ; Myocardial Infarction/epidemiology ; Myocardial Infarction/etiology ; Myocardial Ischemia/epidemiology* ; Myocardial Ischemia/etiology ; Odds Ratio ; Prevalence ; Risk Factors ; Smoking/adverse effects* ; Smoking/epidemiology ; Surveys and Questionnaires
Keywords
vitamin C intake ; Ischemic heart disease ; case-control study ; Republic of Korea
Abstract
OBJECTIVE: Epidemiological data on the relationship between vitamin C intake and ischemic heart disease (IHD) risk are limited in the Asian population, with a high prevalence of smoking. This study aims to investigate the association between vitamin C intake and the incidence of non-fatal IHD in Korean men. METHODS: The case group consisted of 108 patients with electrocardiogram-confirmed myocardial infarction or angiographically confirmed (>or=50% stenosis) coronary artery disease (CAD) who were admitted to a university teaching hospital in Seoul, Korea. The controls were 142 age-matched patients admitted to the departments of ophthalmology and orthopedic surgery at the same hospital. Vitamin C intake was assessed by a nutritionist using a semi-quantitative food frequency method, and body mass index (BMI), tobacco use and past history of cardiovascular disease were determined by examination and interview. RESULTS: After controlling for cardiovascular risk factors, including BMI, smoking, past history of hypertension, past history of hyperlipidemia, dietary intakes of energy, total fat (or subtype of fat), cholesterol, beta-carotene, and vitamin E, the odds ratio (OR) of non-fatal IHD was 0.34 (95% confidence interval (CI) 0.13-0.90) in the highest tertile of vitamin C intake compared with those in the lowest tertile. In a subgroup analysis, which compared nonsmokers in the highest tertile of vitamin C intake to current smokers in the lowest tertile of vitamin C intake, the odds ratio of developing non-fatal IHD was 0.12 (95% CI 0.02-0.77). CONCLUSION: This study suggests that higher intake of vitamin C is associated with the decreased risk of non-fatal IHD in a population with a high prevalence of smoking.
Full Text
http://www.tandfonline.com/doi/abs/10.1080/07315724.2003.10719320
DOI
10.1080/07315724.2003.10719320
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Suh, Il(서일) ORCID logo https://orcid.org/0000-0002-9689-7849
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113400
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