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콩 대사산물이 전립선암에 미치는 효과

Other Titles
 Effects of Soybean Metabolites on Prostate Cancer 
 김원재  ;  이승찬  ;  홍성준  ;  임정식  ;  이상은  ;  윤진한  ;  송재만  ;  장훈 
 KOREAN JOURNAL OF UROLOGY, Vol.44(11) : 1093-1097, 2003 
Journal Title
Issue Date
Isoflavones ; Genistein ; Daidzein ; Equol ; Prostate cancer
Isoflavones ; Genistein ; Daidzein ; Equol ; Prostate cancer
Purpose: It has been postulated that soybean isoflavones act as inhibitory factors in several cancers. Recently, various in vitro and in vivo experimental studies have demonstrated that these isoflavones inhibit prostate cancer. Therefore, we investigated whether soybean isoflavones influenced the development of prostate cancer by comparing the levels of circulating isoflavones between prostate cancer patients and controls. Materials and Methods: The serum levels of genistein, daidzein and equol were determined using reverse-phase, high-performance liquid chromatography-multiple reaction ion monitoring mass spectrometry(HPLC-MS) and compared in 122 experimental subjects(61 prostate cancer patients and 61 cancer-free controls) from 6 hospitals. Results: The serum concentrations of genistein, daidzein and equol in the patients were 130.7⁑181.4ng/ml, 53.6⁑69.3ng/ml and 11.37⁑43.4ng/ml, with control values of 95.6⁑95.2ng/ml, 55.2⁑121.8ng/ml and 23.2⁑34.5ng/ml, respectively. There was no statistical difference between the 2 groups. Daidzein non-metabolizers who were unable to degrade daidzein into equol were compared between the patients and the controls, and were found to be significantly more common in the patient group (p=0.001, OR=3.44, 95% CI=1.6243-7.2855). However, the equol/daidzein ratio was significantly lower in the patients than in the controls(p=0.0072). No association between age, stage, Gleason score or isoflavone concentrations was found. Conclusions: These results suggest that the capability to produce equol (i.e., the mechanism for the metabolism of daidzein into equol) is closely involved in the lower incidence of prostate cancer, and that a diet based on soybean isoflavones would be useful in preventing prostate cancer.
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Hong, Sung Joon(홍성준) ORCID logo https://orcid.org/0000-0001-9869-065X
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