Cited 30 times in
p38 Mitogen-activated protein kinase modulates expression of tumor necrosis factor-related apoptosis-inducing ligand induced by interferon-γ in fetal brain astrocytes
DC Field | Value | Language |
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dc.contributor.author | 김세종 | - |
dc.contributor.author | 신전수 | - |
dc.contributor.author | 최인홍 | - |
dc.date.accessioned | 2015-07-15T16:40:42Z | - |
dc.date.available | 2015-07-15T16:40:42Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0360-4012 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113378 | - |
dc.description.abstract | This study describes the involvement of the p38 mitogen-activated protein kinase (MAPK) during interferon-γ (IFN-γ) signaling in fetal brain astrocytes. In some pathological conditions of brain, p38 MAPK transduces stress-related signals, increases expression of proinflammatory cytokines, and induces cellular damage or apoptosis. In astrocytes, the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) expression level was increased by IFN-γ. AG490, a JAK inhibitor, blocked TRAIL expression induced by IFN-γ. SB203580, a specific p38α and p38β2 MAPK inhibitor, decreased the TRAIL expression induced by IFN-γ. The phosphorylation of the Ser727 site of STAT1, but not the Tyr701 site, was inhibited by SB203580. These results suggest that p38 MAPK modulates STAT1 phosphorylation in IFN-γ signaling in fetal brain astrocytes. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 884~890 | - |
dc.relation.isPartOf | JOURNAL OF NEUROSCIENCE RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Apoptosis/genetics* | - |
dc.subject.MESH | Apoptosis Regulatory Proteins | - |
dc.subject.MESH | Astrocytes/cytology* | - |
dc.subject.MESH | Astrocytes/enzymology | - |
dc.subject.MESH | Astrocytes/metabolism* | - |
dc.subject.MESH | Brain/embryology | - |
dc.subject.MESH | Brain/enzymology | - |
dc.subject.MESH | Brain/metabolism* | - |
dc.subject.MESH | Fetus | - |
dc.subject.MESH | Gene Expression Regulation, Developmental* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interferon-gamma/pharmacology* | - |
dc.subject.MESH | Ligands | - |
dc.subject.MESH | Membrane Glycoproteins/biosynthesis* | - |
dc.subject.MESH | Membrane Glycoproteins/genetics | - |
dc.subject.MESH | Mitogen-Activated Protein Kinases/physiology* | - |
dc.subject.MESH | TNF-Related Apoptosis-Inducing Ligand | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/biosynthesis* | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/genetics | - |
dc.subject.MESH | p38 Mitogen-Activated Protein Kinases | - |
dc.title | p38 Mitogen-activated protein kinase modulates expression of tumor necrosis factor-related apoptosis-inducing ligand induced by interferon-γ in fetal brain astrocytes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | J. Lee | - |
dc.contributor.googleauthor | J.-S. Shin | - |
dc.contributor.googleauthor | I.-H. Choi | - |
dc.contributor.googleauthor | S.-J. Kim | - |
dc.contributor.googleauthor | S.-J. Choi | - |
dc.contributor.googleauthor | D. Kwon | - |
dc.contributor.googleauthor | J.Y. Park | - |
dc.identifier.doi | 10.1002/jnr.10815 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00603 | - |
dc.contributor.localId | A02144 | - |
dc.contributor.localId | A04167 | - |
dc.relation.journalcode | J01634 | - |
dc.identifier.eissn | 1097-4547 | - |
dc.identifier.pmid | 14648593 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/jnr.10815/abstract | - |
dc.subject.keyword | astrocytes | - |
dc.subject.keyword | IFN-y | - |
dc.subject.keyword | p38 kinase | - |
dc.subject.keyword | TRAIL | - |
dc.contributor.alternativeName | Kim, Se Jong | - |
dc.contributor.alternativeName | Shin, Jeon Soo | - |
dc.contributor.alternativeName | Choi, In Hong | - |
dc.contributor.affiliatedAuthor | Kim, Se Jong | - |
dc.contributor.affiliatedAuthor | Shin, Jeon Soo | - |
dc.contributor.affiliatedAuthor | Choi, In Hong | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 74 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 884 | - |
dc.citation.endPage | 890 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROSCIENCE RESEARCH, Vol.74(6) : 884-890, 2003 | - |
dc.identifier.rimsid | 49215 | - |
dc.type.rims | ART | - |
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