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Clinical features of bronchogenic large cell carcinoma confirmed by surgical resection.

 Moo Suk Park  ;  Dong Hwan Shin  ;  Young Sam Kim  ;  Sung Kyu Kim  ;  Joo Hang Kim  ;  Joon Chang  ;  Se Kyu Kim  ;  Do Hoon Kim  ;  Jae Ho Chung  ;  Jae Hee Cheong  ;  Kyung Young Chung 
 KOREAN JOURNAL OF INTERNAL MEDICINE, Vol.18(4) : 212-219, 2003 
Journal Title
Issue Date
Adenocarcinoma/diagnosis ; Adenocarcinoma/epidemiology ; Adenocarcinoma/surgery ; Adolescent ; Adult ; Age Distribution ; Aged ; Carcinoma, Large Cell/diagnosis* ; Carcinoma, Large Cell/epidemiology ; Carcinoma, Large Cell/surgery* ; Female ; Humans ; Lung Neoplasms/diagnosis* ; Lung Neoplasms/epidemiology ; Lung Neoplasms/surgery* ; Male ; Middle Aged ; Prevalence ; Retrospective Studies ; Sex Distribution ; Survival Analysis
Carcinoma ; Large cell ; Diagnosis ; Treatment outcome
BACKGROUND: To define the final outcome of large cell carcinomas (LCC) after surgical treatment, the histopathology, clinical features and follow-up results of 28 cases were reviewed. METHODS: Twenty eight patients, with LCC that underwent a surgical resection between 1986 and 2001, at the Severance Hospital, were retrospectively reviewed. We analyzed clinical data, radiological findings, pathologic findings, treatment modalities, and survival. RESULTS: The prevalence of LCC was 2.9% (29 cases) among the surgically resected primary lung cancer cases (1003 cases) during the 15 year period of the study. The mean age of the patients was 59 years old, with 25 male cases. There were 23 smokers, smoking an average of 33 pack years. A cough was the most frequent symptom. There were 15 cases located in the peripheral part of the lung and 26 consisted of a lobulated mass. From a chest CT scan, 26 cases had necrotic portions, which appeared to be low density. The postoperative stages were IA, IB, IIB, IIIA and IV in 1 (3.6%), 11 (39.3%) 8 (28.5%), 7 (25%), 1 case (3.6%), respectively. The concordance rate of the pre- and postoperative stage was 43%. The median survival time and 5 year-survival rate were 54.5 months and 45%, respectively. CONCLUSION: Our results suggested that a LCC in the lung was predominant in males, and equally located at the center and periphery of the lung in the surgically resected cases. To define the treatment outcome and risk factors of a LCC of the lung, further multicenter studies are needed.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Hoon(김도훈)
Kim, Sung Kyu(김성규)
Kim, Se Kyu(김세규)
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Kim, Joo Hang(김주항)
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Shin, Dong Hwan(신동환)
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
Chung, Kyung Young(정경영)
Chung, Jae Ho(정재호)
Jung, Jae Hee(정재희)
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