치주조직 재생을 위한 칼슘 포스페이트 글라스 분말이 백서 두개골 결손부의 골조직 재생에 미치는 영향

Abstract

The treatment of the bone defects resulting from trauma, neoplasm, surgery, or infection is one of the major concern in dentistry. The major goal is the functional, esthetical regeneration of supporting structures already destructed by disease. Transplantation technique have been used to provide a scaffold for bone regeneration, to augment bony defects resulting from trauma or surgery, to restore bone loss caused by dental disease, to prevent the collapse the alveolar ridge in recent extraction sites, to replace bone loss by periodontal disease, to augment the alveolar ridge in implant surgery. There are autogeneous, allogenic, xenogenic and alloplastic bone-grafts in transplantation. Among the alloplastic bone-graft materials, calcium phosphates have been received the most attention. In this study, the critical size defects were surgically produced in the calvarial bone of Sprague-Dawley rats using the 8 mm trephine bur. Calcium phosphate glass powders with mean diameter 400 micro m transplanted onto the produced defects in the experimental group, while sutured without grafting anything in the control group. Histomorphometric as well as radiodensitometric analyses were performed after sacrifice at 2, 4 and 8 weeks following operation. The prepared calcium phosphate glass powder with average size 400 micro m in CaO-CaF(2)-P(2)O(5)-MgO-Al(2)O(3) promoted new bone formation in the calvarial defects in the Sprague-Dawley rats. New bone was formed in the upper side of the defects as well as the defect margin and dura mater. Experimental group always exhibited higher values in the length, area and density of the newly formed bone than that of the control group. There were significant differences between the experimental and the control groups, except the density after 4 weeks (p<0.05).