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Expressions of transforming growth factor (TGF)-beta1 and TGF-beta type II receptor and their relationship with apoptosis during chemical hepatocarcinogenesis in rats.
DC Field | Value | Language |
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dc.contributor.author | 김철훈 | - |
dc.date.accessioned | 2015-07-15T16:34:52Z | - |
dc.date.available | 2015-07-15T16:34:52Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 1386-6346 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113184 | - |
dc.description.abstract | The expression of transforming growth factor (TGF)-beta1, which regulates cell proliferation, is tightly associated with that of TGF-beta type II receptor (TGR2), and has been regarded as an important change during hepatocarcinogenesis. Our aim in this study was to investigate the expression and localization of TGF-beta1 and TGR2 and to determine their relationships with apoptosis in chemical hepatocarcinogenesis of the rat produced by Solt and Farber's method. Northern blot analysis showed that a slight increase of TGF-beta1 transcripts and a decrease of TGR2 transcripts during hepatocarcinogenesis. Immunohistochemistry revealed that TGF-beta1-positive preneoplastic hepatocytes increased with time, and that this correlated with a reduction TGR2 expressing preneoplastic lesions. Hepatocellular carcinoma (HCC) tissues showed higher levels of TGF-beta1 transcripts and protein and lower levels of TGR2 transcripts and protein compared to the paired adjacent liver parenchyme. TUNEL revealed that apoptotic cells increased with time and were more numerous in the adjacent liver parenchyme than in preneoplastic lesions and HCC tissues. Our data suggest that the down regulation of TGR2 in preneoplastic lesions and HCC tissues might contribute to resistance to the growth inhibitory effects of TGF-beta1, and to the roles of TGF-beta1 in the development and progression of preneoplastic lesions and HCC in a chemically induced rat hepatocarcinogensis model. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | HEPATOLOGY RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | TGF-β1 | - |
dc.subject.MESH | TGF-β type II receptor | - |
dc.subject.MESH | Northern blot | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Apoptosis | - |
dc.subject.MESH | Chemical hepatocarcinogenesis | - |
dc.subject.MESH | Rat | - |
dc.title | Expressions of transforming growth factor (TGF)-beta1 and TGF-beta type II receptor and their relationship with apoptosis during chemical hepatocarcinogenesis in rats. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Do Youn Park | - |
dc.contributor.googleauthor | Mee Young Sol | - |
dc.contributor.googleauthor | Chul Hoon Kim | - |
dc.contributor.googleauthor | Eui-Cheol Shin | - |
dc.contributor.googleauthor | Kang Suek Suh | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01057 | - |
dc.relation.journalcode | J00987 | - |
dc.identifier.eissn | 1872-034X | - |
dc.identifier.pmid | 14585397 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S138663460300264X | - |
dc.subject.keyword | TGF-β1 | - |
dc.subject.keyword | TGF-β type II receptor | - |
dc.subject.keyword | Northern blot | - |
dc.subject.keyword | Immunohistochemistry | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | Chemical hepatocarcinogenesis | - |
dc.subject.keyword | Rat | - |
dc.contributor.alternativeName | Kim, Chul Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Chul Hoon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 27 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 205 | - |
dc.citation.endPage | 213 | - |
dc.identifier.bibliographicCitation | HEPATOLOGY RESEARCH, Vol.27(3) : 205-213, 2003 | - |
dc.identifier.rimsid | 54189 | - |
dc.type.rims | ART | - |
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