Cited 35 times in
Elevated S-phase kinase-associated protein 2 protein expression in acute myelogenous leukemia: its association with constitutive phosphorylation of phosphatase and tensin homologue protein and poor prognosis
DC Field | Value | Language |
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dc.contributor.author | 고윤웅 | - |
dc.contributor.author | 김지연 | - |
dc.contributor.author | 민유홍 | - |
dc.contributor.author | 이승태 | - |
dc.contributor.author | 정준원 | - |
dc.contributor.author | 한지숙 | - |
dc.date.accessioned | 2015-07-14T17:28:32Z | - |
dc.date.available | 2015-07-14T17:28:32Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1078-0432 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112957 | - |
dc.description.abstract | PURPOSE: The F-box protein S-phase kinase-associated protein 2 (Skp2) positively regulates the G(1)-S phase transition by controlling the stability of several G(1) regulators, such as p27Kip1. However, the clinical significance of Skp2 in patients with acute myelogenous leukemia (AML) remains unknown. EXPERIMENTAL DESIGN: We examined the clinical and biological significance of Skp2 expression in AML and evaluated the relationship between Skp2 and p27Kip1 expression and phosphatase and tensin homologue (PTEN) phosphorylation. RESULTS: Western blot analysis showed that high Skp2 expression was observed in 57 (57.6%) cases and significantly correlated with unfavorable cytogenetics (P = 0.035) but not with age, white blood cell count, serum lactic dehydrogenase level, and the French-American-British subtype. An inverse correlation was not observed between Skp2 and p27Kip1 expression. However, p27Kip1 protein was preferentially localized to cytoplasm in the high-Skp2-expression group. The cytoplasmic to nuclear ratio of p27Kip1 expression was significantly correlated with the levels of Skp2 expression (P < 0.001). The frequency of PTEN phosphorylation was significantly higher in the high-Skp2-expression group compared with the low- Skp2-expression group (P = 0.035). The Skp2 overexpression was significantly associated with shorter disease-free survival and overall survival (P = 0.0386 and P = 0.0369, respectively). Multivariate analysis showed that Skp2 expression was an independent prognostic factor both in the disease-free survival and overall survival. CONCLUSION: These findings suggest that Skp2 expression is an independent marker for a poor prognosis in AML. The presence of a positive correlation between Skp2 and phosphorylated PTEN suggests that an aberration in the PTEN/Skp2 signaling pathway might be operating in AML. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 5123~5130 | - |
dc.relation.isPartOf | CLINICAL CANCER RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Cell Cycle | - |
dc.subject.MESH | Cell Cycle Proteins/metabolism | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Nucleus/metabolism | - |
dc.subject.MESH | Cyclin-Dependent Kinase Inhibitor p27 | - |
dc.subject.MESH | Cytogenetics | - |
dc.subject.MESH | Cytoplasm/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | G1 Phase | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Leukemia, Myeloid,Acute/metabolism* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Phosphoric Monoester Hydrolases/metabolism* | - |
dc.subject.MESH | Phosphorylation | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | S Phase | - |
dc.subject.MESH | S-PhaseKinase-AssociatedProteins/biosynthesis* | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Tumor Suppressor Proteins/metabolism | - |
dc.title | Elevated S-phase kinase-associated protein 2 protein expression in acute myelogenous leukemia: its association with constitutive phosphorylation of phosphatase and tensin homologue protein and poor prognosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Medical Research Center (임상의학연구센터) | - |
dc.contributor.googleauthor | Yoo Hong Min | - |
dc.contributor.googleauthor | June-Won Cheong | - |
dc.contributor.googleauthor | Yun Woong Ko | - |
dc.contributor.googleauthor | Jee Sook Hahn | - |
dc.contributor.googleauthor | Seung Tae Lee | - |
dc.contributor.googleauthor | Ji Yeon Kim | - |
dc.contributor.googleauthor | Mark Hong Lee | - |
dc.identifier.doi | 10.1158/1078-0432.CCR-04-0136 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00134 | - |
dc.contributor.localId | A00975 | - |
dc.contributor.localId | A01407 | - |
dc.contributor.localId | A02930 | - |
dc.contributor.localId | A03729 | - |
dc.contributor.localId | A04327 | - |
dc.relation.journalcode | J00564 | - |
dc.identifier.pmid | 15297415 | - |
dc.contributor.alternativeName | Ko, Yun Woong | - |
dc.contributor.alternativeName | Kim, Ji Yeon | - |
dc.contributor.alternativeName | Min, Yoo Hong | - |
dc.contributor.alternativeName | Lee, Seung Tae | - |
dc.contributor.alternativeName | Cheong, June Won | - |
dc.contributor.alternativeName | Hahn, Jee Sook | - |
dc.contributor.affiliatedAuthor | Ko, Yun Woong | - |
dc.contributor.affiliatedAuthor | Kim, Ji Yeon | - |
dc.contributor.affiliatedAuthor | Min, Yoo Hong | - |
dc.contributor.affiliatedAuthor | Lee, Seung Tae | - |
dc.contributor.affiliatedAuthor | Cheong, June-Won | - |
dc.contributor.affiliatedAuthor | Hahn, Jee Sook | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 10 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 5123 | - |
dc.citation.endPage | 5130 | - |
dc.identifier.bibliographicCitation | CLINICAL CANCER RESEARCH, Vol.10(15) : 5123-5130, 2004 | - |
dc.identifier.rimsid | 36821 | - |
dc.type.rims | ART | - |
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