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Isolated Extramedullary Relapse of Acute Myelogenous Leukemia as a Uterine Granulocytic Sarcoma in an Allogeneic Hematopoietic Stem Cell Transplantation Recipient

Authors
 Hoyoung Maeng  ;  June Won Cheong  ;  Yoo Hong Min  ;  Yun Woong Ko  ;  Jee Sook Hahn  ;  Woo Ick Yang  ;  Seung Tae Lee 
Citation
 Yonsei Medical Journal, Vol.45(2) : 330-333, 2004 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2004
MeSH
Adult ; Female ; Hematopoietic Stem Cell Transplantation/adverse effects* ; Humans ; Leukemia, Myeloid, Acute/pathology* ; Leukemia, Myeloid, Acute/therapy* ; Neoplasm Recurrence, Local ; Sarcoma, Myeloid/etiology ; Sarcoma, Myeloid/pathology* ; Uterine Neoplasms/etiology ; Uterine Neoplasms/pathology*
Keywords
Acute myelogenous leukemia ; relapse ; uterus ; bone marrow transplantation
Abstract
We report an unusual case of acute myelogenous leukemia in a patient who showed an extramedullary relapse in her uterus, without bone marrow recurrence, two years after an allogeneic bone marrow transplant. She complained of irregular vaginal spotting, and magnetic resonance imaging demonstrated a uterine mass. A biopsy revealed a massive infiltration of immature myeloid cells. A variable number of tandem repeats (VNTR) based on an examination of peripheral blood cells showed full donor chimerism. After receiving chemotherapy, her uterine mass had completely resolved. She has remained in complete remission for more than 6 months. This case suggests that physicians should be aware of the possibility of a uterine relapse in female bone marrow transplant recipients with acute myelogenous leukemia.
Files in This Item:
T200404417.pdf Download
DOI
10.3349/ymj.2004.45.2.330
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Yun Woong(고윤웅)
Maeng, Ho Young(맹호영)
Min, Yoo Hong(민유홍) ORCID logo https://orcid.org/0000-0001-8542-9583
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Lee, Seung Tae(이승태)
Cheong, June-Won(정준원) ORCID logo https://orcid.org/0000-0002-1744-0921
Hahn, Jee Sook(한지숙)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112955
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