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Isolated Extramedullary Relapse of Acute Myelogenous Leukemia as a Uterine Granulocytic Sarcoma in an Allogeneic Hematopoietic Stem Cell Transplantation Recipient

 Hoyoung Maeng  ;  June Won Cheong  ;  Yoo Hong Min  ;  Yun Woong Ko  ;  Jee Sook Hahn  ;  Woo Ick Yang  ;  Seung Tae Lee 
 Yonsei Medical Journal, Vol.45(2) : 330-333, 2004 
Journal Title
 Yonsei Medical Journal 
Issue Date
We report an unusual case of acute myelogenous leukemia in a patient who showed an extramedullary relapse in her uterus, without bone marrow recurrence, two years after an allogeneic bone marrow transplant. She complained of irregular vaginal spotting, and magnetic resonance imaging demonstrated a uterine mass. A biopsy revealed a massive infiltration of immature myeloid cells. A variable number of tandem repeats (VNTR) based on an examination of peripheral blood cells showed full donor chimerism. After receiving chemotherapy, her uterine mass had completely resolved. She has remained in complete remission for more than 6 months. This case suggests that physicians should be aware of the possibility of a uterine relapse in female bone marrow transplant recipients with acute myelogenous leukemia.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
고윤웅(Ko, Yun Woong)
맹호영(Maeng, Ho Young)
민유홍(Min, Yoo Hong) ORCID logo https://orcid.org/0000-0001-8542-9583
양우익(Yang, Woo Ick) ORCID logo https://orcid.org/0000-0002-6084-5019
이승태(Lee, Seung Tae)
정준원(Cheong, June-Won) ORCID logo https://orcid.org/0000-0002-1744-0921
한지숙(Hahn, Jee Sook)
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