Cited 73 times in
The Homeobox Gene Caudal Regulates Constitutive Local Expression of Antimicrobial Peptide Genes in Drosophila Epithelia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유지환 | - |
dc.contributor.author | 윤주헌 | - |
dc.date.accessioned | 2015-07-14T17:28:02Z | - |
dc.date.available | 2015-07-14T17:28:02Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0270-7306 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112940 | - |
dc.description.abstract | In Drosophila melanogaster, although the NF-κB transcription factors play a pivotal role in the inducible expression of innate immune genes, such as antimicrobial peptide genes, the exact regulatory mechanism of the tissue-specific constitutive expression of these genes in barrier epithelia is largely unknown. Here, we show that the Drosophila homeobox gene product Caudal functions as the innate immune transcription modulator that is responsible for the constitutive local expression of antimicrobial peptides cecropin and drosomycin in a tissue-specific manner. These results suggest that certain epithelial tissues have evolved a unique constitutive innate immune strategy by recruiting a developmental “master control” gene. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 172~185 | - |
dc.relation.isPartOf | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | AntimicrobialCationic Peptides/biosynthesis | - |
dc.subject.MESH | AntimicrobialCationic Peptides/genetics* | - |
dc.subject.MESH | DrosophilaProteins | - |
dc.subject.MESH | Drosophilamelanogaster/genetics* | - |
dc.subject.MESH | Drosophilamelanogaster/metabolism | - |
dc.subject.MESH | Epithelium/metabolism* | - |
dc.subject.MESH | Homeodomain Proteins/genetics* | - |
dc.subject.MESH | Homeodomain Proteins/metabolism | - |
dc.subject.MESH | Immunity, Innate/physiology | - |
dc.subject.MESH | Promoter Regions, Genetic | - |
dc.subject.MESH | Transcription Factors | - |
dc.title | The Homeobox Gene Caudal Regulates Constitutive Local Expression of Antimicrobial Peptide Genes in Drosophila Epithelia | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | 생체방어연구센터 | - |
dc.contributor.googleauthor | Ji-Hwan Ryu | - |
dc.contributor.googleauthor | Ki-Bum Nam | - |
dc.contributor.googleauthor | Won-Jae Lee | - |
dc.contributor.googleauthor | Paul T. Brey | - |
dc.contributor.googleauthor | In-Hwan Jang | - |
dc.contributor.googleauthor | Mi-Ae Yoo | - |
dc.contributor.googleauthor | Je-Kyeong Seong | - |
dc.contributor.googleauthor | Joo-Heon Yoon | - |
dc.contributor.googleauthor | Sung-Hee Kim | - |
dc.contributor.googleauthor | Hyuck-Jin Nam | - |
dc.contributor.googleauthor | Chun-Taek Oh | - |
dc.identifier.doi | 10.1128/MCB.24.1.172-185.2004 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02604 | - |
dc.contributor.localId | A02522 | - |
dc.relation.journalcode | J02243 | - |
dc.identifier.eissn | 1098-5549 | - |
dc.identifier.pmid | 14673153 | - |
dc.contributor.alternativeName | Ryu, Ji Hwan | - |
dc.contributor.alternativeName | Yoon, Joo Heon | - |
dc.contributor.affiliatedAuthor | Yoon, Joo Heon | - |
dc.contributor.affiliatedAuthor | Ryu, Ji Hwan | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 24 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 172 | - |
dc.citation.endPage | 185 | - |
dc.identifier.bibliographicCitation | MOLECULAR AND CELLULAR BIOLOGY, Vol.24(1) : 172-185, 2004 | - |
dc.identifier.rimsid | 36811 | - |
dc.type.rims | ART | - |
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