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파제트병과 동반된 유방암에서 Anaphase Promoting Complex (APC)와 APC조절 단백의 발현

Other Titles
 Expression of Anaphase Promoting Complex (APC) and APC Regulatory Proteins in Invasive Ductal Carcinoma Associated with Paget's Disease 
 박광화  ;  이상엽  ;  이광길  ;  강엽  ;  양우익 
 KOREAN JOURNAL OF PATHOLOGY , Vol.38(5) : 319-323, 2004 
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Issue Date
Paget’s disease-Breast Cancer-Anaphase Promoting Complex-Cyclin B1- PTTG
Background : Oncogene expression in Paget's disease of the breast is not well known. To characterize invasive ductal carcinoma associated with Paget's disease, we studied expres-sion of anaphase promoting complex (APC) with its regulatory proteins. Methods : Immuno-histochemical stainings were done with 10 cases of invasive ductal carcinoma associated with Paget's disease for APC, pituitary tumor transforming gene (PTTG), cyclin B1, p53, cyclin D1, and c-erbB-2. The expressions of these markers in Paget's disease were compared with those in the associated with carcinoma. Results : APC, PTTG, cyclin B1, and c-erbB-2 were positive in all of the cases with both Paget's disease and underlying carcinoma. p53 was expressed in Paget's disease of 6 cases (60%) and in carcinoma of 7 cases (70%). Cyclin D1 was positive in Paget's disease of 8 cases (80%) and in carcinoma of 9 cases (90%). Conclusions : Breast carcinomas with Paget's disease seem to be distinguished by the high expression of APC, cyclin B1, PTTG, c-erbB2, and cyclin D1 in contrast to breast can-cers without Paget's disease. Furthermore, the similar expression pattems of APC and APC regulatory proteins in both Paget’s disease and underlying breast cancer support the epider-motropic theory as its pathogenetic mechanism.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
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