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HDL 콜레스테롤의 유전율과 유전자 분리모형 연구

Other Titles
 Heritability and segregation analysis of the level of HDL-cholesterol 
 윤지은  ;  남정모  ;  지선하  ;  서일 
 Korean Journal of Epidemiology, Vol.26(2) : 43-53, 2004 
Journal Title
Korean Journal of Epidemiology(한국역학회지)
Issue Date
Heritablity ; Segregation analysis ; HDL-cholesterol
Objectives: The purpose of this study was to investigate the familial correlation and heritability in HDL cholesterol through segregation analysis.

Methods: This study, based on data from 11,117 Korean individuals ascertained pedigrees who had participated in 1998 and 2001 Korean National Health & Nutrition Examination Survey. The subjects of segregation analysis were 4,688 Korean who had more than five members in their family.

Results: Serum lipid levels revealed strong familial correlation among spouses, parent-offspring and siblings with low correlation of spouse. The heritability of HDL cholesterol was 54.8% after controlling for age, age², gender, age × gender, waist circumference, smoking, alcohol drinking, exercise and education.

Two models of inheritance, the Mendelian dominant model and the Mendelian codominant model were found in HDL cholesterol. In the codominant model, the predicted HDL-cholesterol for genotype AA, AB, and BB were 44.96, 49.13, and 69.67 mg/dl, respectively. However the Mendelian eodominant model only was found in high risk families.

Conclusions: In conclusion, randomly ascertained Korean families of this study showed strong familial aggregation in HDL cholesterol. The results suggested that the variations in HDL cholesterol may be influencing by major effect of gene.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Suh, Il(서일) ORCID logo https://orcid.org/0000-0002-9689-7849
Yun, Ji Eun(윤지은)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
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